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• W1780931672 abstract "Ethionamide (ETH) and prothionamide (PTH), both thioamides, have proven efficacy in clinical studies and form important components for multidrug-resistant tuberculosis treatment regimens and for treatment of tuberculous meningitis in adults and children. ETH and PTH are pro-drugs that, following enzymatic activation by mycobacterial EthA inhibit InhA, a target shared with isoniazid (INH), and subsequently inhibit mycolic acid synthesis of Mycobacterium tuberculosis. Co-resistance to INH and ETH is conferred by mutations in the mycobacterial inhA promoter region; mutations in the ethA gene often underlie ETH and PTH monoresistance. An oral daily dose of ETH or PTH of 15-20 mg/kg with a maximum daily dose of 1000 mg is recommended in children to achieve adult-equivalent serum concentrations shown to be efficacious in adults, although information on optimal pharmacodynamic targets is still lacking. Gastrointestinal disturbances, and hypothyroidism during long-term therapy, are frequent adverse effects observed in adults and children, but are rarely life-threatening and seldom necessitate cessation of ETH therapy. More thorough investigation of the therapeutic effects and toxicity of ETH and PTH is needed in childhood TB while child-friendly formulations are needed to appropriately dose children." @default.
• W1780931672 created "2016-06-24" @default.
• W1780931672 creator A5001170851 @default.
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• W1780931672 creator A5052781811 @default.
• W1780931672 date "2016-03-01" @default.
• W1780931672 modified "2023-10-03" @default.
• W1780931672 title "A review of the use of ethionamide and prothionamide in childhood tuberculosis" @default.
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• W1780931672 doi "https://doi.org/10.1016/j.tube.2015.09.007" @default.
• W1780931672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26586647" @default.

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