FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1781119783> ?p ?o ?g. }

• W1781119783 endingPage "1129" @default.
• W1781119783 startingPage "1123" @default.
• W1781119783 abstract "Phosphorylation of glutamate receptors (GluRs) is emerging as an important regulatory mechanism. In this study 32P labeling of non-NMDA GluRs was investigated in cultured hippocampal neurons stimulated 2-15 min with agonists that selectively stimulate either Ca2+/calmodulin-dependent protein kinase II (CaM-kinase II), Ca2+/phospholipid-dependent protein kinase C (PKC), or cAMP-dependent protein kinase A (PKA). Treatment of hippocampal neurons with glutamate/glycine (Glu/Gly), ionomycin, or 12-O-tetradecanoylphorbol 13-acetate (TPA) increased 32P labeling of immunoprecipitated alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionate (AMPA)-type GluRs by 145%, 180%, and 227%, respectively, of control values. This increased phosphorylation of GluRs was predominantly 32P-Ser with little 32P-Thr and no detectable 32P-Tyr. Glu/Gly and ionomycin, but not TPA, also increased 32P labeling of CaM-kinase II by 175% and 195%, respectively, of control values. Of these three agonists, only TPA stimulated phosphorylation of MARCKS (225% of control), a specific substrate of PKC. Forskolin treatment gave a three- to fourfold increase in the active catalytic subunit of PKA but did not result in the 32P labeling of AMPA-type GluRs, CaM-kinase II, or MARCKS. Phosphorylation of GluRs in response to Glu/Gly was blocked by a specific NMDA receptor/ion channel antagonist (DL-2-amino-5-phosphonovaleric acid) or by a cell-permeable inhibitor of CaM-kinase II (1-[N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4- phenylpiperazine, KN-62). These results are consistent with the hypothesis that Ca2+ influx through the NMDA-type ion channel can activate CaM-kinase II, which in turn can phosphorylate and regulate AMPA-type GluR ion channels (McGlade-McCulloh et al., 1993).(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W1781119783 created "2016-06-24" @default.
• W1781119783 creator A5019591445 @default.
• W1781119783 creator A5022304025 @default.
• W1781119783 creator A5049515511 @default.
• W1781119783 date "1994-03-01" @default.
• W1781119783 modified "2023-10-12" @default.
• W1781119783 title "Phosphorylation of AMPA-type glutamate receptors by calcium/calmodulin- dependent protein kinase II and protein kinase C in cultured hippocampal neurons" @default.
• W1781119783 cites W1525266792 @default.
• W1781119783 cites W1538865085 @default.
• W1781119783 cites W1548600249 @default.
• W1781119783 cites W1568808038 @default.
• W1781119783 cites W1580245730 @default.
• W1781119783 cites W1599345755 @default.
• W1781119783 cites W1602379280 @default.
• W1781119783 cites W1659153222 @default.
• W1781119783 cites W173376292 @default.
• W1781119783 cites W1970706135 @default.
• W1781119783 cites W1977529115 @default.
• W1781119783 cites W1986245436 @default.
• W1781119783 cites W1988189113 @default.
• W1781119783 cites W2003861265 @default.
• W1781119783 cites W2008520902 @default.
• W1781119783 cites W2010920096 @default.
• W1781119783 cites W2012952905 @default.
• W1781119783 cites W2014269618 @default.
• W1781119783 cites W2035880579 @default.
• W1781119783 cites W2045434651 @default.
• W1781119783 cites W2054975255 @default.
• W1781119783 cites W2057826234 @default.
• W1781119783 cites W2065307585 @default.
• W1781119783 cites W2066322829 @default.
• W1781119783 cites W2082691527 @default.
• W1781119783 cites W2094046904 @default.
• W1781119783 cites W2099597342 @default.
• W1781119783 cites W2100837269 @default.
• W1781119783 cites W2126578889 @default.
• W1781119783 cites W2409025422 @default.
• W1781119783 doi "https://doi.org/10.1523/jneurosci.14-03-01123.1994" @default.
• W1781119783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6577568" @default.
• W1781119783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7509863" @default.
• W1781119783 hasPublicationYear "1994" @default.
• W1781119783 type Work @default.
• W1781119783 sameAs 1781119783 @default.
• W1781119783 citedByCount "181" @default.
• W1781119783 countsByYear W17811197832012 @default.
• W1781119783 countsByYear W17811197832013 @default.
• W1781119783 countsByYear W17811197832014 @default.
• W1781119783 countsByYear W17811197832015 @default.
• W1781119783 countsByYear W17811197832016 @default.
• W1781119783 countsByYear W17811197832017 @default.
• W1781119783 countsByYear W17811197832018 @default.
• W1781119783 countsByYear W17811197832019 @default.
• W1781119783 countsByYear W17811197832021 @default.
• W1781119783 countsByYear W17811197832023 @default.
• W1781119783 crossrefType "journal-article" @default.
• W1781119783 hasAuthorship W1781119783A5019591445 @default.
• W1781119783 hasAuthorship W1781119783A5022304025 @default.
• W1781119783 hasAuthorship W1781119783A5049515511 @default.
• W1781119783 hasBestOaLocation W17811197831 @default.
• W1781119783 hasConcept C11960822 @default.
• W1781119783 hasConcept C153911025 @default.
• W1781119783 hasConcept C160268369 @default.
• W1781119783 hasConcept C170493617 @default.
• W1781119783 hasConcept C184235292 @default.
• W1781119783 hasConcept C185592680 @default.
• W1781119783 hasConcept C195794163 @default.
• W1781119783 hasConcept C2776989580 @default.
• W1781119783 hasConcept C55493867 @default.
• W1781119783 hasConcept C61174792 @default.
• W1781119783 hasConcept C67018056 @default.
• W1781119783 hasConcept C79879829 @default.
• W1781119783 hasConcept C86803240 @default.
• W1781119783 hasConcept C95444343 @default.
• W1781119783 hasConcept C97029542 @default.
• W1781119783 hasConceptScore W1781119783C11960822 @default.
• W1781119783 hasConceptScore W1781119783C153911025 @default.
• W1781119783 hasConceptScore W1781119783C160268369 @default.
• W1781119783 hasConceptScore W1781119783C170493617 @default.
• W1781119783 hasConceptScore W1781119783C184235292 @default.
• W1781119783 hasConceptScore W1781119783C185592680 @default.
• W1781119783 hasConceptScore W1781119783C195794163 @default.
• W1781119783 hasConceptScore W1781119783C2776989580 @default.
• W1781119783 hasConceptScore W1781119783C55493867 @default.
• W1781119783 hasConceptScore W1781119783C61174792 @default.
• W1781119783 hasConceptScore W1781119783C67018056 @default.
• W1781119783 hasConceptScore W1781119783C79879829 @default.
• W1781119783 hasConceptScore W1781119783C86803240 @default.
• W1781119783 hasConceptScore W1781119783C95444343 @default.
• W1781119783 hasConceptScore W1781119783C97029542 @default.
• W1781119783 hasIssue "3" @default.
• W1781119783 hasLocation W17811197831 @default.
• W1781119783 hasLocation W17811197832 @default.
• W1781119783 hasLocation W17811197833 @default.
• W1781119783 hasLocation W17811197834 @default.
• W1781119783 hasOpenAccess W1781119783 @default.
• W1781119783 hasPrimaryLocation W17811197831 @default.
• W1781119783 hasRelatedWork W1502257144 @default.

• next