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• W1781457705 abstract "Altered activity of the hypothalamus–pituitary–adrenal (HPA) stress-axis has been implicated in the pathogenesis and progression of multiple sclerosis (MS) and linked to the development of specific symptoms and comorbidities such as mood disorders, fatigue, or cognitive dysfunction. Overall the HPA-axis is activated or hyperresponsive in MS, though a hyporesponsive HPA-axis has been observed in a subgroup of MS patients that has a more severe course of the disease. Here we provide an overview of the possible causes of HPA-axis activation, sex- and subtype dependent differences, pathological, cellular, and molecular effects, and the clinical correlates of HPA-axis activity in MS." @default.
• W1781457705 created "2016-06-24" @default.
• W1781457705 creator A5005739479 @default.
• W1781457705 creator A5012932735 @default.
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• W1781457705 date "2021-01-01" @default.
• W1781457705 modified "2023-10-11" @default.
• W1781457705 title "The stress-axis in multiple sclerosis: Clinical, cellular, and molecular aspects" @default.
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• W1781457705 doi "https://doi.org/10.1016/b978-0-12-820683-6.00008-7" @default.
• W1781457705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34238451" @default.
• W1781457705 hasPublicationYear "2021" @default.
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