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- W178148415 abstract "People with HIV infection are living longer as a result of advances in combinationantiretroviral therapy. This increase in lifespan has been coupled with an increasein the prevalence of HIV associated neurocognitive decline (HAND). A centralfeature of this presentation is the impairment of executive functioning, and theaim of this study was to explore whether there is general impairment of thisdomain or whether there is an executive function profile (of deficits versusrelatively preserved aspects of function) in people with HAND.Sixteen participants with HAND (mean age = 49.25 years, range 23 to 72 years)were recruited from an inpatient HIV-rehabilitation unit, and completed cognitiveand executive function batteries.The executive function profile obtained at group level suggested impairments inworking memory, verbal initiation, verbal inhibition, rule induction, and processingspeed abilities. In contrast letter fluency and visuo-spatial switching scores wereless affected.Case series analyses indicated that cognitive and executive functioning variedwidely within the participant sample. However verbal initiation and inhibition wereimpaired in all profiles, indicating these impairments are prominent in the earlystages of disease.The findings of this study indicate that it may be beneficial for clinicians to useexecutive function batteries when assessing for HAND, since a thoroughassessment of this multi-faceted cognitive domain can support more informedclinical decision-making. Further, the study suggests which tests may be clinicallyuseful in detecting executive function deficits in HAND." @default.
- W178148415 created "2016-06-24" @default.
- W178148415 creator A5074431749 @default.
- W178148415 date "2014-05-01" @default.
- W178148415 modified "2023-09-27" @default.
- W178148415 title "Executive Function Deficits in HIV-Associated Neurocognitive Decline" @default.
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