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• W1781637164 abstract "The molecular recognition properties of the oligosaccharide chains of glycoproteins and glycolipids are often characterized in terms of their interactions with lectins. Binding of multivalent lectins to cells often leads to cross-linking and aggregation of specific glycoprotein and glycolipid receptors, with concomitant biological responses. Furthermore, lectin-induced cross-linking of transmembrane glycoproteins leads to changes in their interactions with cytoskeletal proteins and concomitant alterations in the mobility and aggregation of other surface receptors. A number of mammalian lectins are involved in receptor-mediated endocytosis of glycoproteins, whereas others have been implicated in cellular recognition processes including apoptosis and metastasis. In general, multivalent protein–carbohydrate interactions increase the affinity and specificity of monovalent interactions by two means. First, multivalent carbohydrate binding to a lectin possessing multiple subsites per subunit results in large increases in the affinity of interaction. Second, binding of a multivalent carbohydrate to a lectin possessing a single binding site per subunit can result in smaller increases in affinity and, under the appropriate stoichiometric conditions, cross-linking of lectin molecules by the carbohydrate leading to type 1 or 2 complexes. Because of the importance in understanding the structural and thermodynamic basis of lectin–carbohydrate cross-linking interactions and their biological significance, a combination of methods including quantitative precipitation analysis, precipitation kinetics, electron microscopy, X-ray powder diffraction, model building, X-ray crystallography, isothermal titration calorimetry, and confocal microscopy has been employed to study these interactions. These methods, their applications, and findings are discussed in this chapter." @default.
• W1781637164 created "2016-06-24" @default.
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• W1781637164 date "2003-01-01" @default.
• W1781637164 modified "2023-09-25" @default.
• W1781637164 title "Carbohydrate–Lectin Cross-Linking Interactions: Structural, Thermodynamic, and Biological Studies" @default.
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• W1781637164 doi "https://doi.org/10.1016/s0076-6879(03)01031-0" @default.
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