FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W178180852> ?p ?o ?g. }

• W178180852 endingPage "89" @default.
• W178180852 startingPage "73" @default.
• W178180852 abstract "The platelet is a specialized adhesive cell that plays a key role in thrombus formation under both physiological and pathological blood flow conditions. Platelet adhesion and activation are dynamic processes associated with rapid morphological and functional changes, with the earliest signaling events occurring over a subsecond time-scale. The relatively small size of platelets combined with the dynamic nature of platelet adhesion under blood flow means that the investigation of platelet signaling events requires techniques with both high spatial discrimination and rapid temporal resolution. Unraveling the complex signaling processes governing platelet adhesive function under conditions of hemodynamic shear stress has been a longstanding goal in platelet research and has been greatly influenced by the development and application of microimaging-based techniques. Advances in the area of epi-fluorescence and confocal-based platelet calcium (Ca(2+)) imaging have facilitated the in vitro and in vivo elucidation of the early signaling events regulating platelet adhesion and activation. These studies have identified distinct Ca(2+) signaling mechanisms that serve to dynamically regulate activation of the major platelet integrin α(IIb)β(3) and associated adhesion and aggregation processes under flow. This chapter describes in detail a ratiometric calcium imaging protocol and associated troubleshooting procedures developed in our laboratory to examine live platelet Ca(2+) signaling dynamics. This technique provides a method for high-resolution imaging of the Ca(2+) dynamics underpinning platelet adhesion and thrombus formation under conditions of pathophysiological shear stress." @default.
• W178180852 created "2016-06-24" @default.
• W178180852 creator A5004925172 @default.
• W178180852 creator A5023005054 @default.
• W178180852 creator A5048624587 @default.
• W178180852 creator A5050936754 @default.
• W178180852 creator A5091111962 @default.
• W178180852 date "2011-11-17" @default.
• W178180852 modified "2023-09-27" @default.
• W178180852 title "A Live Cell Micro-imaging Technique to Examine Platelet Calcium Signaling Dynamics Under Blood Flow" @default.
• W178180852 cites W147356149 @default.
• W178180852 cites W1485297825 @default.
• W178180852 cites W1604015258 @default.
• W178180852 cites W1969927282 @default.
• W178180852 cites W1971004719 @default.
• W178180852 cites W1971529415 @default.
• W178180852 cites W1976738617 @default.
• W178180852 cites W1977613097 @default.
• W178180852 cites W1984282445 @default.
• W178180852 cites W1986506306 @default.
• W178180852 cites W1990200619 @default.
• W178180852 cites W1994864391 @default.
• W178180852 cites W1995095741 @default.
• W178180852 cites W2001529103 @default.
• W178180852 cites W2007206486 @default.
• W178180852 cites W2009400023 @default.
• W178180852 cites W2012347765 @default.
• W178180852 cites W2020687188 @default.
• W178180852 cites W2022339423 @default.
• W178180852 cites W2038337449 @default.
• W178180852 cites W2042659329 @default.
• W178180852 cites W2057599460 @default.
• W178180852 cites W2057826063 @default.
• W178180852 cites W2068262290 @default.
• W178180852 cites W2084830465 @default.
• W178180852 cites W2141088469 @default.
• W178180852 cites W2149580070 @default.
• W178180852 cites W2164033349 @default.
• W178180852 cites W2167506939 @default.
• W178180852 cites W2169437261 @default.
• W178180852 cites W4237588890 @default.
• W178180852 cites W4247741685 @default.
• W178180852 doi "https://doi.org/10.1007/978-1-61779-307-3_6" @default.
• W178180852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22130701" @default.
• W178180852 hasPublicationYear "2011" @default.
• W178180852 type Work @default.
• W178180852 sameAs 178180852 @default.
• W178180852 citedByCount "9" @default.
• W178180852 countsByYear W1781808522013 @default.
• W178180852 countsByYear W1781808522016 @default.
• W178180852 countsByYear W1781808522017 @default.
• W178180852 countsByYear W1781808522018 @default.
• W178180852 countsByYear W1781808522019 @default.
• W178180852 countsByYear W1781808522022 @default.
• W178180852 countsByYear W1781808522023 @default.
• W178180852 crossrefType "book-chapter" @default.
• W178180852 hasAuthorship W178180852A5004925172 @default.
• W178180852 hasAuthorship W178180852A5023005054 @default.
• W178180852 hasAuthorship W178180852A5048624587 @default.
• W178180852 hasAuthorship W178180852A5050936754 @default.
• W178180852 hasAuthorship W178180852A5091111962 @default.
• W178180852 hasConcept C12554922 @default.
• W178180852 hasConcept C126322002 @default.
• W178180852 hasConcept C1491633281 @default.
• W178180852 hasConcept C178790620 @default.
• W178180852 hasConcept C185592680 @default.
• W178180852 hasConcept C195687474 @default.
• W178180852 hasConcept C201571599 @default.
• W178180852 hasConcept C203014093 @default.
• W178180852 hasConcept C2780009322 @default.
• W178180852 hasConcept C2781362458 @default.
• W178180852 hasConcept C2993802102 @default.
• W178180852 hasConcept C3018697912 @default.
• W178180852 hasConcept C519063684 @default.
• W178180852 hasConcept C55493867 @default.
• W178180852 hasConcept C62478195 @default.
• W178180852 hasConcept C71924100 @default.
• W178180852 hasConcept C84416704 @default.
• W178180852 hasConcept C85789140 @default.
• W178180852 hasConcept C86803240 @default.
• W178180852 hasConcept C89560881 @default.
• W178180852 hasConcept C95444343 @default.
• W178180852 hasConceptScore W178180852C12554922 @default.
• W178180852 hasConceptScore W178180852C126322002 @default.
• W178180852 hasConceptScore W178180852C1491633281 @default.
• W178180852 hasConceptScore W178180852C178790620 @default.
• W178180852 hasConceptScore W178180852C185592680 @default.
• W178180852 hasConceptScore W178180852C195687474 @default.
• W178180852 hasConceptScore W178180852C201571599 @default.
• W178180852 hasConceptScore W178180852C203014093 @default.
• W178180852 hasConceptScore W178180852C2780009322 @default.
• W178180852 hasConceptScore W178180852C2781362458 @default.
• W178180852 hasConceptScore W178180852C2993802102 @default.
• W178180852 hasConceptScore W178180852C3018697912 @default.
• W178180852 hasConceptScore W178180852C519063684 @default.
• W178180852 hasConceptScore W178180852C55493867 @default.
• W178180852 hasConceptScore W178180852C62478195 @default.
• W178180852 hasConceptScore W178180852C71924100 @default.

• next