FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1781834802> ?p ?o ?g. }

• W1781834802 endingPage "136" @default.
• W1781834802 startingPage "127" @default.
• W1781834802 abstract "High-dose radiation may improve outcomes in non-small-cell lung cancer (NSCLC). By using three-dimensional conformal radiation therapy and limiting the target volume, we hypothesized that the dose could be safely escalated.A standard phase I design was used. Five bins were created based on the volume of normal lung irradiated, and dose levels within bins were chosen based on the estimated risk of radiation pneumonitis. Starting doses ranged from 63 to 84 Gy given in 2.1-Gy fractions. Target volumes included the primary tumor and any nodes >or= 1 cm on computed tomography. Clinically uninvolved nodal regions were not included purposely. More recently, selected patients received neoadjuvant cisplatin and vinorelbine.At the time of this writing, 104 patients had been enrolled. Twenty-four had stage I, four had stage II, 43 had stage IIIA, 26 had stage IIIB, and seven had locally recurrent disease. Twenty-five received chemotherapy, and 63 were assessable for escalation. All bins were escalated at least twice. Although grade 2 radiation pneumonitis occurred in five patients, grade 3 radiation pneumonitis occurred in only two. The maximum-tolerated dose was only established for the largest bin, at 65.1 Gy. Dose levels for the four remaining bins were 102.9, 102.9, 84 and 75.6 Gy. The majority of patients failed distantly, though a significant proportion also failed in the target volume. There were no isolated failures in clinically uninvolved nodal regions.Dose escalation in NSCLC has been accomplished safely in most patients using three-dimensional conformal radiation therapy, limiting target volumes, and segregating patients by the volume of normal lung irradiated." @default.
• W1781834802 created "2016-06-24" @default.
• W1781834802 creator A5007644996 @default.
• W1781834802 creator A5014527725 @default.
• W1781834802 creator A5020101072 @default.
• W1781834802 creator A5034493174 @default.
• W1781834802 creator A5034993321 @default.
• W1781834802 creator A5043319397 @default.
• W1781834802 creator A5044315254 @default.
• W1781834802 creator A5056753589 @default.
• W1781834802 creator A5056886978 @default.
• W1781834802 creator A5064028169 @default.
• W1781834802 date "2001-01-01" @default.
• W1781834802 modified "2023-09-26" @default.
• W1781834802 title "Dose Escalation in Non–Small-Cell Lung Cancer Using Three-Dimensional Conformal Radiation Therapy: Update of a Phase I Trial" @default.
• W1781834802 cites W1817196311 @default.
• W1781834802 cites W1832274547 @default.
• W1781834802 cites W1944220675 @default.
• W1781834802 cites W1960413044 @default.
• W1781834802 cites W1964624837 @default.
• W1781834802 cites W1975081329 @default.
• W1781834802 cites W1985859085 @default.
• W1781834802 cites W1995102805 @default.
• W1781834802 cites W2002089674 @default.
• W1781834802 cites W2007517846 @default.
• W1781834802 cites W2014145691 @default.
• W1781834802 cites W2015579738 @default.
• W1781834802 cites W2016035176 @default.
• W1781834802 cites W2022326226 @default.
• W1781834802 cites W2022774277 @default.
• W1781834802 cites W2023670264 @default.
• W1781834802 cites W2027226834 @default.
• W1781834802 cites W2027381633 @default.
• W1781834802 cites W2031555443 @default.
• W1781834802 cites W2033456044 @default.
• W1781834802 cites W2040399379 @default.
• W1781834802 cites W2041332468 @default.
• W1781834802 cites W2045559867 @default.
• W1781834802 cites W2046672004 @default.
• W1781834802 cites W2048716754 @default.
• W1781834802 cites W2054385160 @default.
• W1781834802 cites W2055092775 @default.
• W1781834802 cites W2057616211 @default.
• W1781834802 cites W2061581927 @default.
• W1781834802 cites W2073573926 @default.
• W1781834802 cites W2092377688 @default.
• W1781834802 cites W2093374013 @default.
• W1781834802 cites W2097512974 @default.
• W1781834802 cites W2121562131 @default.
• W1781834802 cites W2138310931 @default.
• W1781834802 cites W2141983610 @default.
• W1781834802 cites W2155053061 @default.
• W1781834802 cites W2160234796 @default.
• W1781834802 cites W2162095136 @default.
• W1781834802 cites W2226077283 @default.
• W1781834802 cites W2312703485 @default.
• W1781834802 cites W4233003855 @default.
• W1781834802 cites W4246724402 @default.
• W1781834802 doi "https://doi.org/10.1200/jco.2001.19.1.127" @default.
• W1781834802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11134205" @default.
• W1781834802 hasPublicationYear "2001" @default.
• W1781834802 type Work @default.
• W1781834802 sameAs 1781834802 @default.
• W1781834802 citedByCount "302" @default.
• W1781834802 countsByYear W17818348022012 @default.
• W1781834802 countsByYear W17818348022013 @default.
• W1781834802 countsByYear W17818348022014 @default.
• W1781834802 countsByYear W17818348022015 @default.
• W1781834802 countsByYear W17818348022016 @default.
• W1781834802 countsByYear W17818348022017 @default.
• W1781834802 countsByYear W17818348022018 @default.
• W1781834802 countsByYear W17818348022019 @default.
• W1781834802 countsByYear W17818348022020 @default.
• W1781834802 countsByYear W17818348022021 @default.
• W1781834802 countsByYear W17818348022022 @default.
• W1781834802 crossrefType "journal-article" @default.
• W1781834802 hasAuthorship W1781834802A5007644996 @default.
• W1781834802 hasAuthorship W1781834802A5014527725 @default.
• W1781834802 hasAuthorship W1781834802A5020101072 @default.
• W1781834802 hasAuthorship W1781834802A5034493174 @default.
• W1781834802 hasAuthorship W1781834802A5034993321 @default.
• W1781834802 hasAuthorship W1781834802A5043319397 @default.
• W1781834802 hasAuthorship W1781834802A5044315254 @default.
• W1781834802 hasAuthorship W1781834802A5056753589 @default.
• W1781834802 hasAuthorship W1781834802A5056886978 @default.
• W1781834802 hasAuthorship W1781834802A5064028169 @default.
• W1781834802 hasConcept C126322002 @default.
• W1781834802 hasConcept C126838900 @default.
• W1781834802 hasConcept C143998085 @default.
• W1781834802 hasConcept C146357865 @default.
• W1781834802 hasConcept C151730666 @default.
• W1781834802 hasConcept C2776256026 @default.
• W1781834802 hasConcept C2776694085 @default.
• W1781834802 hasConcept C2777714996 @default.
• W1781834802 hasConcept C2778239845 @default.
• W1781834802 hasConcept C2779524853 @default.
• W1781834802 hasConcept C2780350996 @default.
• W1781834802 hasConcept C2989005 @default.

• next