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• W1782317462 abstract "The transcriptional imbalance due to the difference in the number of X chromosomes between male and female mammals is remedied through X-chromosome inactivation, the epigenetic transcriptional silencing of one of the two X chromosomes in females. The X-linked Xist long non-coding RNA functions as an X inactivation master regulator; Xist is selectively upregulated from the prospective inactive X chromosome and is required in cis for X inactivation. Here we discover an Xist antisense long non-coding RNA, XistAR (Xist Activating RNA), which is encoded within exon 1 of the mouse Xist gene and is transcribed only from the inactive X chromosome. Selective truncation of XistAR, while sparing the overlapping Xist RNA, leads to a deficiency in Xist RNA expression in cis during the initiation of X inactivation. Thus, the Xist gene carries within its coding sequence an antisense RNA that drives Xist expression." @default.
• W1782317462 created "2016-06-24" @default.
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• W1782317462 date "2015-10-19" @default.
• W1782317462 modified "2023-10-12" @default.
• W1782317462 title "An Xist-activating antisense RNA required for X-chromosome inactivation" @default.
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• W1782317462 doi "https://doi.org/10.1038/ncomms9564" @default.
• W1782317462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4616153" @default.
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