Matches in SemOpenAlex for { <https://semopenalex.org/work/W17824827> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W17824827 abstract "Aims To study the effects of unsaturated high-fat diet on myocardial structure, contractile function and energy metabolism in rats with supravalvar aortic stenosis (SVAS), diastolic dysfunction and improved systolic function. We hypothesized that increased energy supply attenuates hypertrophy, diastolic dysfunction and preserves systolic function in SVAS. Methods Male Wistar rats (80g) underwent SVAS or Sham surgery (n=24/group); after 6 weeks were redistributed into four groups (n=12/group): normolipidic (Sham-N and SVAS-N) or hyperlipidic chow (Sham-H and SVAS-H) for 12 weeks. Cardiac remodeling was evaluated by echocardiogram in the 6th and 18th week; macroscopy and glycolysis and beta oxidation enzymes were evaluated in the 18th week. Results In the 6th week, echocardiogram showed that SVAS had hypertrophy, diastolic dysfunction, evidenced by increased left atrium (LA), and improved systolic function. In the 18th week, atrium weight (AT) and AT/tibia ratio were lower in SVAS-H vs SVAS-N. Echocardiogram showed preserved systolic function in SVAS groups; LA/BW ratio was lower in SVAS-H vs SVAS-N; LA (p=0.10) and LA/AO (p<0.06) tended to be lower in SVAS-H vs SVAS-N. Metabolic enzymes were similar among groups. Conclusion High-fat diet attenuated diastolic dysfunction, evidenced by decreased atrial hypertrophy; it did not involve energy metabolism alterations. Financial support: FAPESP" @default.
- W17824827 created "2016-06-24" @default.
- W17824827 creator A5036564520 @default.
- W17824827 creator A5037305321 @default.
- W17824827 creator A5053157812 @default.
- W17824827 creator A5056013660 @default.
- W17824827 creator A5062200344 @default.
- W17824827 creator A5065219227 @default.
- W17824827 creator A5068978711 @default.
- W17824827 creator A5089503335 @default.
- W17824827 date "2013-04-01" @default.
- W17824827 modified "2023-10-14" @default.
- W17824827 title "Effects of a high‐fat diet on the cardiac dysfunction and energy metabolism in rats with supravalvar aortic stenosis" @default.
- W17824827 doi "https://doi.org/10.1096/fasebj.27.1_supplement.lb419" @default.
- W17824827 hasPublicationYear "2013" @default.
- W17824827 type Work @default.
- W17824827 sameAs 17824827 @default.
- W17824827 citedByCount "0" @default.
- W17824827 crossrefType "journal-article" @default.
- W17824827 hasAuthorship W17824827A5036564520 @default.
- W17824827 hasAuthorship W17824827A5037305321 @default.
- W17824827 hasAuthorship W17824827A5053157812 @default.
- W17824827 hasAuthorship W17824827A5056013660 @default.
- W17824827 hasAuthorship W17824827A5062200344 @default.
- W17824827 hasAuthorship W17824827A5065219227 @default.
- W17824827 hasAuthorship W17824827A5068978711 @default.
- W17824827 hasAuthorship W17824827A5089503335 @default.
- W17824827 hasConcept C111566952 @default.
- W17824827 hasConcept C126322002 @default.
- W17824827 hasConcept C134018914 @default.
- W17824827 hasConcept C164705383 @default.
- W17824827 hasConcept C167414201 @default.
- W17824827 hasConcept C2778198053 @default.
- W17824827 hasConcept C2780007028 @default.
- W17824827 hasConcept C2781290252 @default.
- W17824827 hasConcept C57900726 @default.
- W17824827 hasConcept C71924100 @default.
- W17824827 hasConcept C84393581 @default.
- W17824827 hasConceptScore W17824827C111566952 @default.
- W17824827 hasConceptScore W17824827C126322002 @default.
- W17824827 hasConceptScore W17824827C134018914 @default.
- W17824827 hasConceptScore W17824827C164705383 @default.
- W17824827 hasConceptScore W17824827C167414201 @default.
- W17824827 hasConceptScore W17824827C2778198053 @default.
- W17824827 hasConceptScore W17824827C2780007028 @default.
- W17824827 hasConceptScore W17824827C2781290252 @default.
- W17824827 hasConceptScore W17824827C57900726 @default.
- W17824827 hasConceptScore W17824827C71924100 @default.
- W17824827 hasConceptScore W17824827C84393581 @default.
- W17824827 hasIssue "S1" @default.
- W17824827 hasLocation W178248271 @default.
- W17824827 hasOpenAccess W17824827 @default.
- W17824827 hasPrimaryLocation W178248271 @default.
- W17824827 hasRelatedWork W169677309 @default.
- W17824827 hasRelatedWork W1981654342 @default.
- W17824827 hasRelatedWork W1993394218 @default.
- W17824827 hasRelatedWork W2014629399 @default.
- W17824827 hasRelatedWork W2034302244 @default.
- W17824827 hasRelatedWork W2159629462 @default.
- W17824827 hasRelatedWork W2233348272 @default.
- W17824827 hasRelatedWork W2318787838 @default.
- W17824827 hasRelatedWork W2409998376 @default.
- W17824827 hasRelatedWork W3160140598 @default.
- W17824827 hasVolume "27" @default.
- W17824827 isParatext "false" @default.
- W17824827 isRetracted "false" @default.
- W17824827 magId "17824827" @default.
- W17824827 workType "article" @default.