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- W1782792012 abstract "Objective . To evaluate outcomes of cultivated limbal epithelial transplantation (CLET) for management of ocular surface failure due to limbal stem cell deficiency (LSCD). Design . Prospective, noncomparative, interventional case series and extensive comparison with recent similar studies. Participants . Twenty eyes with LSCD underwent CLET (11 autologous; 9 allogeneic) and were followed up for 3 years. Etiologies were divided into 3 prognostic categories: Group 1, chemical injuries (7 eyes); Group 2, immune-based inflammation (4 eyes); and Group 3, noninflammatory diseases (9 eyes). Intervention . Autologous and allogeneic limbal epithelial cells were cultivated on amniotic membranes and transplanted. Evaluations were based on clinical parameters, survival analysis, and in vivo confocal microscopy (IVCM). European Union Tissues/Cells Directive and good manufacturing procedures were followed. Main Outcome Measures . Improved clinical parameters, absence of epithelial defects, and improved central corneal epithelial phenotype. Results . Success rate was 80% at 1-2 years and 75% at 3 years. Autografts and allografts had similar survival. Success rate was significantly lower in prognostic Group 1 (42.9%) than in Groups 2-3 (100% each). All clinical parameters improved substantially. By IVCM, 80% of cases improved in epithelial status. Conclusions . CLET improved corneal epithelium quality, with subsequent improvement in symptoms, quality of life, and vision. These results confirm that CLET is a valid therapy for ocular surface failure." @default.
- W1782792012 created "2016-06-24" @default.
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- W1782792012 date "2015-01-01" @default.
- W1782792012 modified "2023-10-18" @default.
- W1782792012 title "Stem Cell Therapy for Corneal Epithelium Regeneration following Good Manufacturing and Clinical Procedures" @default.
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- W1782792012 doi "https://doi.org/10.1155/2015/408495" @default.
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