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• W1782886592 abstract "MicroRNAs are emerging as important regulators of cancer-related processes. Our studies show that microRNA-9 (miR-9) is downregulated in human ovarian cancer relative to normal ovary, and overexpression of miR-9 suppresses cell growth in vitro. Furthermore, the 3′-UTR of NF-κB1 mRNA is found to be regulated directly by miR-9, demonstrating that NF-κB1 is a functionally important target of miR-9 in ovarian cancer cells. When miR-9 is overexpressed in ovarian cancer cells, the mRNA and protein levels of NF-κB1 are both suppressed, whereas inhibition of miR-9 results in an increase in the NF-κB1 expression level. Ovarian cancer tissues display significantly low expression of miR-9 and a high level of NF-κB1 compared with normal tissues, indicating that regulation of NF-κB1 by miR-9 is an important mechanism for miR-9 to inhibit ovarian cancer proliferation." @default.
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• W1782886592 date "2009-08-21" @default.
• W1782886592 modified "2023-10-18" @default.
• W1782886592 title "MicroRNA-9 inhibits ovarian cancer cell growth through regulation of NF-κB1" @default.
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• W1782886592 doi "https://doi.org/10.1111/j.1742-4658.2009.07237.x" @default.
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