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- W178291922 endingPage "84" @default.
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- W178291922 abstract "Using a transient expression system of mouse IgM mini-gene constructs in mouse B-cell lines and in fibroblast L cell, we investigated splicing of the IgM transcript. We observed that the efficiency of splicing between exons C4 and M1 (C4-to-M1 splicing), the splicing reaction leading to the production of membrane-bound form (microns) mRNA, was drastically affected by mutations in a specific portion of the downstream exon (M2). The results show that the specific exon M2 sequence activates the C4-to-M1 splicing. This activation was not observed when splicing between exons M1 and M2 was abolished by base substitutions at the splice sites. These results indicate that positioning of the downstream exon is crucial for efficient splicing of the preceding intron." @default.
- W178291922 created "2016-06-24" @default.
- W178291922 creator A5029852466 @default.
- W178291922 creator A5083782157 @default.
- W178291922 creator A5090653578 @default.
- W178291922 date "1991-01-01" @default.
- W178291922 modified "2023-09-23" @default.
- W178291922 title "Repositioning of an alternative exon sequence of mouse IgM pre-mRNA activates splicing of the preceding intron." @default.
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- W178291922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5952188" @default.
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