Matches in SemOpenAlex for { <https://semopenalex.org/work/W1782947185> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1782947185 endingPage "686" @default.
- W1782947185 startingPage "685" @default.
- W1782947185 abstract "To the Editor: The cell membrane permeability and the intracellular accumulation of borocaptate (BSH) were recently investigated by Ono et al. (1). These questions are of great importance with regard to boron neutron capture therapy (BNCT) for cancer, which completely relies on a selective uptake and accumulation of boron into the tumor cells, prior to irradiation with thermal neutrons. In particular, the uptake of BSH in glioblastoma multiforme (GBM) is debated. The GBM is characterized by its infiltrative growth and an extensive migration of individual tumor cells, which may form clusters far away from the bulk of the tumor. These distant metastases are surrounded by otherwise healthy brain tissue with an intact blood–brain barrier prohibiting any direct uptake of boron compounds administered intravenously. However, according to our own findings in an experimental animal model (the RG2 rat glioma), BSH in the blood may reach these distant metastases through another route, namely via passive leakage into the tumor followed by capillary transport along the same nerve-fiber tracts that carry the migrating tumor cells (2). Whether or not the BSH actually enters into the tumor cells, however, is not as well known. The work of Ono and coworkers is therefore of great interest, bearing in mind the limitations of experiments with cultured cells. Relying on the extremely local effect of the neutron-capture reaction in boron, these authors investigated the cell membrane permeability of BSH indirectly by studying the cell-killing efficacy of thermal-neutron irradiation. Notably, they found that given enough time, BSH seems to slowly penetrate the cell membranes and remain intracellular even after washing." @default.
- W1782947185 created "2016-06-24" @default.
- W1782947185 creator A5004175173 @default.
- W1782947185 creator A5059959971 @default.
- W1782947185 creator A5061513988 @default.
- W1782947185 date "2000-02-01" @default.
- W1782947185 modified "2023-09-25" @default.
- W1782947185 doi "https://doi.org/10.1016/s0360-3016(99)00449-6" @default.
- W1782947185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10701751" @default.
- W1782947185 hasPublicationYear "2000" @default.
- W1782947185 type Work @default.
- W1782947185 sameAs 1782947185 @default.
- W1782947185 citedByCount "0" @default.
- W1782947185 crossrefType "journal-article" @default.
- W1782947185 hasAuthorship W1782947185A5004175173 @default.
- W1782947185 hasAuthorship W1782947185A5059959971 @default.
- W1782947185 hasAuthorship W1782947185A5061513988 @default.
- W1782947185 hasConcept C121332964 @default.
- W1782947185 hasConcept C121608353 @default.
- W1782947185 hasConcept C12554922 @default.
- W1782947185 hasConcept C126322002 @default.
- W1782947185 hasConcept C142724271 @default.
- W1782947185 hasConcept C1491633281 @default.
- W1782947185 hasConcept C152568617 @default.
- W1782947185 hasConcept C27251351 @default.
- W1782947185 hasConcept C2778227246 @default.
- W1782947185 hasConcept C2779130545 @default.
- W1782947185 hasConcept C2989005 @default.
- W1782947185 hasConcept C3020616263 @default.
- W1782947185 hasConcept C502942594 @default.
- W1782947185 hasConcept C55493867 @default.
- W1782947185 hasConcept C62520636 @default.
- W1782947185 hasConcept C71924100 @default.
- W1782947185 hasConcept C79879829 @default.
- W1782947185 hasConcept C86803240 @default.
- W1782947185 hasConcept C95444343 @default.
- W1782947185 hasConcept C96232424 @default.
- W1782947185 hasConceptScore W1782947185C121332964 @default.
- W1782947185 hasConceptScore W1782947185C121608353 @default.
- W1782947185 hasConceptScore W1782947185C12554922 @default.
- W1782947185 hasConceptScore W1782947185C126322002 @default.
- W1782947185 hasConceptScore W1782947185C142724271 @default.
- W1782947185 hasConceptScore W1782947185C1491633281 @default.
- W1782947185 hasConceptScore W1782947185C152568617 @default.
- W1782947185 hasConceptScore W1782947185C27251351 @default.
- W1782947185 hasConceptScore W1782947185C2778227246 @default.
- W1782947185 hasConceptScore W1782947185C2779130545 @default.
- W1782947185 hasConceptScore W1782947185C2989005 @default.
- W1782947185 hasConceptScore W1782947185C3020616263 @default.
- W1782947185 hasConceptScore W1782947185C502942594 @default.
- W1782947185 hasConceptScore W1782947185C55493867 @default.
- W1782947185 hasConceptScore W1782947185C62520636 @default.
- W1782947185 hasConceptScore W1782947185C71924100 @default.
- W1782947185 hasConceptScore W1782947185C79879829 @default.
- W1782947185 hasConceptScore W1782947185C86803240 @default.
- W1782947185 hasConceptScore W1782947185C95444343 @default.
- W1782947185 hasConceptScore W1782947185C96232424 @default.
- W1782947185 hasIssue "3" @default.
- W1782947185 hasLocation W17829471851 @default.
- W1782947185 hasLocation W17829471852 @default.
- W1782947185 hasOpenAccess W1782947185 @default.
- W1782947185 hasPrimaryLocation W17829471851 @default.
- W1782947185 hasRelatedWork W1597336749 @default.
- W1782947185 hasRelatedWork W2093183459 @default.
- W1782947185 hasRelatedWork W2153210794 @default.
- W1782947185 hasRelatedWork W2339808165 @default.
- W1782947185 hasRelatedWork W2344637265 @default.
- W1782947185 hasRelatedWork W2760056981 @default.
- W1782947185 hasRelatedWork W2783732652 @default.
- W1782947185 hasRelatedWork W2974647127 @default.
- W1782947185 hasRelatedWork W3049178086 @default.
- W1782947185 hasRelatedWork W3215939181 @default.
- W1782947185 hasVolume "46" @default.
- W1782947185 isParatext "false" @default.
- W1782947185 isRetracted "false" @default.
- W1782947185 magId "1782947185" @default.
- W1782947185 workType "article" @default.