FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1783645304> ?p ?o ?g. }

• W1783645304 endingPage "1486" @default.
• W1783645304 startingPage "1477" @default.
• W1783645304 abstract "Diarylpyrimidine (DAPY) derivatives, one family of HIV non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) with superior activities against wild-type (WT) HIV-1 and NNRTI-resistant strains, have attracted much attention in the past decade. A series of DAPY derivatives featuring a fluorine atom on the central ring were reported as novel NNRTIs in the patent WO2014072419. Some compounds exhibited robust potency against both WT and mutant strains, which were approximately equal to or higher than those of the reference drug TMC120. Moreover, it has become evident that fluorinated molecules have a remarkable record in many other potent NNRTIs. Thus, this survey provides a sampling of renowned fluorinated NNRTIs and their mode of action, with an analysis clarifying the functional roles and impact of fluorine substitution on antiviral potency. We envision that fluorinated NNRTIs will play a continuing role in affording anti-HIV drug candidates for therapeutic applications." @default.
• W1783645304 created "2016-06-24" @default.
• W1783645304 creator A5016395926 @default.
• W1783645304 creator A5035724323 @default.
• W1783645304 creator A5045545412 @default.
• W1783645304 creator A5056072753 @default.
• W1783645304 creator A5059468550 @default.
• W1783645304 date "2015-09-28" @default.
• W1783645304 modified "2023-10-11" @default.
• W1783645304 title "Novel fluorine-containing DAPY derivatives as potent HIV-1 NNRTIs: a patent evaluation of WO2014072419" @default.
• W1783645304 cites W1911648303 @default.
• W1783645304 cites W1977842149 @default.
• W1783645304 cites W1983125013 @default.
• W1783645304 cites W1983401069 @default.
• W1783645304 cites W1985062379 @default.
• W1783645304 cites W1986527828 @default.
• W1783645304 cites W1986569038 @default.
• W1783645304 cites W1988775904 @default.
• W1783645304 cites W1995498089 @default.
• W1783645304 cites W1999436953 @default.
• W1783645304 cites W2000267913 @default.
• W1783645304 cites W2003299861 @default.
• W1783645304 cites W2007434340 @default.
• W1783645304 cites W2009699727 @default.
• W1783645304 cites W2012187236 @default.
• W1783645304 cites W2017788003 @default.
• W1783645304 cites W2019850388 @default.
• W1783645304 cites W2020300294 @default.
• W1783645304 cites W2020631657 @default.
• W1783645304 cites W2023883416 @default.
• W1783645304 cites W2027111155 @default.
• W1783645304 cites W2032730999 @default.
• W1783645304 cites W2033043158 @default.
• W1783645304 cites W2038163403 @default.
• W1783645304 cites W2038775337 @default.
• W1783645304 cites W2053818792 @default.
• W1783645304 cites W2062231842 @default.
• W1783645304 cites W2063380198 @default.
• W1783645304 cites W2071358460 @default.
• W1783645304 cites W2078710896 @default.
• W1783645304 cites W2080043305 @default.
• W1783645304 cites W2080291668 @default.
• W1783645304 cites W2085140092 @default.
• W1783645304 cites W2088978277 @default.
• W1783645304 cites W2092178115 @default.
• W1783645304 cites W2095397920 @default.
• W1783645304 cites W2098018059 @default.
• W1783645304 cites W2115419571 @default.
• W1783645304 cites W2116087305 @default.
• W1783645304 cites W2118785491 @default.
• W1783645304 cites W2122296176 @default.
• W1783645304 cites W2138190435 @default.
• W1783645304 cites W2140310496 @default.
• W1783645304 cites W2149148148 @default.
• W1783645304 cites W2151768713 @default.
• W1783645304 cites W2156548893 @default.
• W1783645304 cites W2159065552 @default.
• W1783645304 cites W2160184406 @default.
• W1783645304 cites W2160753576 @default.
• W1783645304 cites W2168926375 @default.
• W1783645304 cites W224505985 @default.
• W1783645304 cites W2320052056 @default.
• W1783645304 cites W2325377306 @default.
• W1783645304 cites W2918044000 @default.
• W1783645304 cites W4215670 @default.
• W1783645304 doi "https://doi.org/10.1517/13543776.2016.1088832" @default.
• W1783645304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26415039" @default.
• W1783645304 hasPublicationYear "2015" @default.
• W1783645304 type Work @default.
• W1783645304 sameAs 1783645304 @default.
• W1783645304 citedByCount "8" @default.
• W1783645304 countsByYear W17836453042017 @default.
• W1783645304 countsByYear W17836453042018 @default.
• W1783645304 countsByYear W17836453042022 @default.
• W1783645304 countsByYear W17836453042023 @default.
• W1783645304 crossrefType "journal-article" @default.
• W1783645304 hasAuthorship W1783645304A5016395926 @default.
• W1783645304 hasAuthorship W1783645304A5035724323 @default.
• W1783645304 hasAuthorship W1783645304A5045545412 @default.
• W1783645304 hasAuthorship W1783645304A5056072753 @default.
• W1783645304 hasAuthorship W1783645304A5059468550 @default.
• W1783645304 hasConcept C104317684 @default.
• W1783645304 hasConcept C121587506 @default.
• W1783645304 hasConcept C156719811 @default.
• W1783645304 hasConcept C159047783 @default.
• W1783645304 hasConcept C178790620 @default.
• W1783645304 hasConcept C185592680 @default.
• W1783645304 hasConcept C202751555 @default.
• W1783645304 hasConcept C21951064 @default.
• W1783645304 hasConcept C2780035454 @default.
• W1783645304 hasConcept C3013748606 @default.
• W1783645304 hasConcept C506198293 @default.
• W1783645304 hasConcept C55493867 @default.
• W1783645304 hasConcept C57992300 @default.
• W1783645304 hasConcept C67705224 @default.
• W1783645304 hasConcept C71240020 @default.
• W1783645304 hasConcept C86803240 @default.
• W1783645304 hasConcept C98274493 @default.

• next