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- W1783832431 abstract "Dietary Ca exerts an anti-obesity effect, and dairy exerts ~ twice the activity as supplemental Ca. Milk contain angiotensin converting enzyme inhibitors (ACEi) and a high concentration of branched chain amino acids (BCAA), both of which may contribute to an anti-obesity effect through effects on lipid metabolism and muscle protein synthesis, respectively. To test this hypothesis, aP2-agouti transgenic mice were maintained for 6 weeks on an obesigenic soy based diet and then randomized into an ad libitum control group and energy restricted (70% of ad lib) containing soy protein (0.4% Ca), non-fat dry milk (NFDM; 1.2% Ca) or Ca-depleted NFDM (0.4% Ca) for an additional 6 weeks; the soy diet was provided with or without an ACEi and BCAA supplement and provided at either 0.4 or 1.2% Ca. The NFDM group exhibited ~2-fold greater reduction in body weight and fat than the energy restricted group (p<0.01), and the Ca-depleted milk group exerted 60% of the effect of intact milk (p<0.01); this effect was recapitulated by the ACEi/BCAA supplemented diet, and addition of Ca to this diet resulted in further weight and fat loss; overall, the Ca, ACEi and BCAA content of milk accounted for ~90% of its anti-obesity activity. The milk or BCAA diets all protected against loss of muscle mass. These data indicate that Ca is responsible for ~40% of the anti-obesity effect of milk whileBCAA and ACEi is responsible for most of the additional activity." @default.
- W1783832431 created "2016-06-24" @default.
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- W1783832431 date "2007-04-01" @default.
- W1783832431 modified "2023-10-13" @default.
- W1783832431 title "Role of branched chain amino acids and ACE inhibition in the anti‐obesity effect of milk" @default.
- W1783832431 doi "https://doi.org/10.1096/fasebj.21.5.a328-a" @default.
- W1783832431 hasPublicationYear "2007" @default.
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