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- W1784060230 abstract "The liver-type and muscle-type isozymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase are encoded by one gene that uses two alternative promoters. We have identified cis-acting sequences and protein-binding sites on the liver-type promoter. Transfection assays with deleted promoters showed that maximal promoter activity is contained within 360 bp upstream of the cap site. DNase I footprinting experiments with liver and spleen nuclear extracts and with purified proteins revealed several protein-binding sites in this region. These included four binding sites for nuclear factor I, one site that contains an octamer consensus but showed a liver-specific footprint pattern, two liver-specific protein-binding sites, and one poly(dG)-containing binding site. Transfection of cells of hepatic origin suggested that all these sites except one are involved in transcriptional regulation. The region between -360 and -2663 contained an element that functioned as a silencer in a nonhepatic cell line. We conclude that in liver transcription from the liver-type promoter of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene is controlled by ubiquitous and tissue-specific factors and involves activating and derepressing mechanisms." @default.
- W1784060230 created "2016-06-24" @default.
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- W1784060230 date "1991-02-01" @default.
- W1784060230 modified "2023-09-25" @default.
- W1784060230 title "Identification of Regulatory Sequences and Protein-Binding Sites in the Liver-Type Promoter of a Gene Encoding 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase" @default.
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- W1784060230 doi "https://doi.org/10.1128/mcb.11.2.1099-1106.1991" @default.
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