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• W1784546543 abstract "Background : Colorectal cancer, a major health concern worldwide, is the third most common form of cancer and second leading cause of cancer-related deaths. The flavonoids are naturally occurring diphenylpropanoids ubiquitous in plant foods and important components of the human diet. Luteolin, a bioflavonoid, possesses many beneficial effects including antioxidant, anti-inflammatory, anti-allergic activities. Methods :We used the HCT-15 colon adenocarcinoma cell line in this study. Cells were treated with luteolin (100 µM). Results : Membrane damage markers such as alkaline phosphatase and lactate dehydrogenase were analyzed in a time-dependent manner. Luteolin increased reactive oxygen species in a time-dependent manner. DNA damage, a hallmark of apoptosis, was induced by luteolin as analyzed by agarose gel electrophoresis. Conclusion : Luteolin acts as a potential cytotoxic agent that can be used to treat colorectal cancer." @default.
• W1784546543 created "2016-06-24" @default.
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• W1784546543 date "2013-10-01" @default.
• W1784546543 modified "2023-09-26" @default.
• W1784546543 title "Cytotoxic Effect of Luteolin on Human Colorectal Cancer Cell Line (HCT-15): Crucial Involvement of Reactive Oxygen Species" @default.
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