Matches in SemOpenAlex for { <https://semopenalex.org/work/W1784579433> ?p ?o ?g. }
- W1784579433 endingPage "954" @default.
- W1784579433 startingPage "941" @default.
- W1784579433 abstract "Vγ9Vδ2 T cells have the ability to produce inflammatory cytokines involved in protective immunity against intracellular pathogens and tumours and to display strong cytolytic as well as bactericidal activities. This suggests a direct involvement of Vγ9Vδ2 T lymphocytes in immune control of cancer and infections. These observations have recently aided development of novel immunotherapeutic approaches aimed at Vγ9Vδ2 T cell activation. Nitrogen-containing bisphosphonates (N-BPs) play a crucial role in Vγ9Vδ2 T lymphocyte activation and in the acquisition of effector functions. The preliminary results of these innovative strategies are encouraging. Moreover, compelling evidence in the literature supports the hypothesis that the antitumour effect of bisphosphonates is exerted through direct as well as indirect mechanisms. An additional and not yet well explored mechanism by which N-BPs may display antineoplastic effect is related to their immunomodulatory properties. It is fascinating that N-BPs influence the immune system in various but interrelated ways, being able to enhance the innate and to promote the adaptive immune responses. For all these reasons, Vγ9Vδ2 T lymphocytes represent a particularly interesting target for immunotherapeutic protocols based on N-BP administration. All these unexpected effects of N-BPs on the immune system have opened new and intriguing possibilities of therapeutic use for these drugs." @default.
- W1784579433 created "2016-06-24" @default.
- W1784579433 creator A5003629514 @default.
- W1784579433 creator A5010991352 @default.
- W1784579433 creator A5025063054 @default.
- W1784579433 creator A5044044058 @default.
- W1784579433 creator A5044162653 @default.
- W1784579433 creator A5059367989 @default.
- W1784579433 creator A5081470600 @default.
- W1784579433 creator A5086599840 @default.
- W1784579433 date "2007-07-01" @default.
- W1784579433 modified "2023-09-27" @default.
- W1784579433 title "Immunomodulating role of bisphosphonates on human gamma delta T cells: an intriguing and promising aspect of their antitumour activity" @default.
- W1784579433 cites W1484185978 @default.
- W1784579433 cites W1488882307 @default.
- W1784579433 cites W1535243328 @default.
- W1784579433 cites W153696494 @default.
- W1784579433 cites W1549471387 @default.
- W1784579433 cites W1569244831 @default.
- W1784579433 cites W1574421689 @default.
- W1784579433 cites W1638058526 @default.
- W1784579433 cites W169247656 @default.
- W1784579433 cites W1764179577 @default.
- W1784579433 cites W1897499866 @default.
- W1784579433 cites W1920167267 @default.
- W1784579433 cites W1948558382 @default.
- W1784579433 cites W1963713418 @default.
- W1784579433 cites W1971761379 @default.
- W1784579433 cites W1972120590 @default.
- W1784579433 cites W1975107690 @default.
- W1784579433 cites W1984131196 @default.
- W1784579433 cites W1984736619 @default.
- W1784579433 cites W1987608235 @default.
- W1784579433 cites W1987742719 @default.
- W1784579433 cites W1995181451 @default.
- W1784579433 cites W2001060310 @default.
- W1784579433 cites W2003692790 @default.
- W1784579433 cites W2003797329 @default.
- W1784579433 cites W2008985536 @default.
- W1784579433 cites W2020056291 @default.
- W1784579433 cites W2021563247 @default.
- W1784579433 cites W2024887507 @default.
- W1784579433 cites W2026391181 @default.
- W1784579433 cites W2031276908 @default.
- W1784579433 cites W2031650256 @default.
- W1784579433 cites W2032719886 @default.
- W1784579433 cites W2041367424 @default.
- W1784579433 cites W2042094925 @default.
- W1784579433 cites W2044794329 @default.
- W1784579433 cites W2045369683 @default.
- W1784579433 cites W2054759185 @default.
- W1784579433 cites W2064414491 @default.
- W1784579433 cites W2066639236 @default.
- W1784579433 cites W2071507149 @default.
- W1784579433 cites W2072693298 @default.
- W1784579433 cites W2073475836 @default.
- W1784579433 cites W2074890088 @default.
- W1784579433 cites W2076107807 @default.
- W1784579433 cites W2082300581 @default.
- W1784579433 cites W2083601518 @default.
- W1784579433 cites W2084651782 @default.
- W1784579433 cites W2089484373 @default.
- W1784579433 cites W2093164779 @default.
- W1784579433 cites W2095554275 @default.
- W1784579433 cites W2098136315 @default.
- W1784579433 cites W2098528749 @default.
- W1784579433 cites W2109484445 @default.
- W1784579433 cites W2112194579 @default.
- W1784579433 cites W2112660458 @default.
- W1784579433 cites W2113294064 @default.
- W1784579433 cites W2114951959 @default.
- W1784579433 cites W2124166505 @default.
- W1784579433 cites W2125212648 @default.
- W1784579433 cites W2125994015 @default.
- W1784579433 cites W2126044591 @default.
- W1784579433 cites W2130046741 @default.
- W1784579433 cites W2130967257 @default.
- W1784579433 cites W2134920558 @default.
- W1784579433 cites W2135189342 @default.
- W1784579433 cites W2136000098 @default.
- W1784579433 cites W2136450035 @default.
- W1784579433 cites W2140457510 @default.
- W1784579433 cites W2141884093 @default.
- W1784579433 cites W2144860907 @default.
- W1784579433 cites W2149707203 @default.
- W1784579433 cites W2150060394 @default.
- W1784579433 cites W2152662617 @default.
- W1784579433 cites W2153265866 @default.
- W1784579433 cites W2154839101 @default.
- W1784579433 cites W2160129587 @default.
- W1784579433 cites W2160907388 @default.
- W1784579433 cites W2163819348 @default.
- W1784579433 cites W2170263258 @default.
- W1784579433 cites W2171068988 @default.
- W1784579433 cites W2325302070 @default.
- W1784579433 cites W2336678594 @default.
- W1784579433 cites W2615372951 @default.
- W1784579433 cites W3026107450 @default.