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- W1784667903 abstract "Hepatic levels of the cytochrome P450 (CYP) proteins 2E1 and 4A are often increased in obesity, diabetes and fasting. In such states of nutritional imbalance, CYPs 2E1 and 4A may play a more significant role in fatty acid oxidation. In order to more fully characterize the regulation of CYP2E1 and CYP4A in obesity and obesity-related (type II) diabetes, we analyzed the hepatic expression ofCYP2E1andCYP4Ainob/obmice which are leptin deficient, andfa/faZucker rats which have defective leptin receptor function. CYP2E1 protein and mRNA were either unchanged or reduced in both models. Conversely, expression of murine Cyp4a10 and 4a14 in the obese mice, and 4A2 in the male fatty Zucker rat, were greatly increased. The levels of other CYP4As were either unchanged or reduced. These results show that CYP2E1 is not inevitably increased by obesity and diabetes and indicate differential regulation of CYP4A subfamily genes in rodent models. Further, they implicate leptin receptor signaling as a factor that may modulate expression of CYP gene products involved in fatty acid oxidation." @default.
- W1784667903 created "2016-06-24" @default.
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- W1784667903 date "1999-02-01" @default.
- W1784667903 modified "2023-10-16" @default.
- W1784667903 title "Altered Expression of HepaticCYP2E1andCYP4Ain Obese, Diabeticob/obMice, andfa/faZucker Rats" @default.
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- W1784667903 doi "https://doi.org/10.1006/bbrc.1999.0202" @default.
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