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• W1785114938 endingPage "2951" @default.
• W1785114938 startingPage "2946" @default.
• W1785114938 abstract "Nuclear factor I (NFI) is composed of a family of site-specific DNA-binding proteins which recognize a DNA-binding site with the consensus sequence TGGC/A(N)5GCCAA. Binding sites for NFI have previously been shown to stimulate mRNA synthesis in vitro when present upstream of the TATA box of the adenovirus major late promoter (AdMLP). We have examined the effect of NFI-binding sites on transcription in vivo in transiently transfected HeLa and COS cells. An NFI-binding site isolated from the human genome activated expression from the minimal AdMLP in vivo in both the absence and presence of the simian virus 40 enhancer. A point mutation that decreased NFI binding affinity for the site in vitro reduced expression to near the basal level of the AdMLP. Several NFI-binding sites which differed in their spacer and flanking sequences were tested for their ability to activate expression in vivo. The ability of these sites to activate expression correlated with the strength of NFI binding in vitro. An NFI-binding site stimulated expression equally well when placed from 33 to 65 bp upstream of the TATA box. However, expression dropped to basal levels when the site was located from 71 to 77 bp upstream of the TATA box. These studies indicate that an NFI-binding site in this chimeric promoter activates expression in vivo only if located within a critical distance of the TATA box." @default.
• W1785114938 created "2016-06-24" @default.
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• W1785114938 creator A5068644454 @default.
• W1785114938 date "1991-06-01" @default.
• W1785114938 modified "2023-09-27" @default.
• W1785114938 title "In vivo stimulation of a chimeric promoter by binding sites for nuclear factor I" @default.
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• W1785114938 doi "https://doi.org/10.1128/mcb.11.6.2946-2951.1991" @default.
• W1785114938 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/360121" @default.
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• W1785114938 hasPublicationYear "1991" @default.
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