FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1785183744> ?p ?o ?g. }

• W1785183744 endingPage "305" @default.
• W1785183744 startingPage "299" @default.
• W1785183744 abstract "Optimal treatment for stable repaired tetralogy of Fallot (rTOF) patients with pulmonary regurgitation (PR) and related right ventricular (RV) dilatation, including timing of valve implantation, remains uncertain. We sought to study tolerability of the angiotensin-converting-enzyme (ACE) inhibitor ramipril and its effects on cardiovascular function in these patients.Clinically stable rTOF patients with moderate/severe PR were included. A double-blinded, placebo-controlled study of 6 months of ramipril vs placebo was performed. All patients underwent cardiovascular magnetic resonance (CMR), echocardiography, neurohormonal analysis, and objective cardiopulmonary exercise testing at baseline and follow-up.The main aim was to detect changes in RV function (primary endpoint CMR-derived RV ejection fraction).Seventy-two patients were enrolled and 64 qualified for the final analysis. There was no difference in the primary endpoint RV ejection fraction. RV long-axis shortening significantly improved in the ramipril group compared to placebo (RV: 2.3 ± 3.8 vs 0.02 ± 2.7 mm; P=0.017) as did LV long-axis shortening (1.9 ± 4.5 vs -0.2 ± 3.7 mm respectively; P=0.030). No clear differences were detected between ramipril and placebo for other measures. In a subgroup of patients with restrictive RV physiology, ramipril resulted in decrease in LV end-systolic volume index and increase in LVEF (-2.4 ± 5.0 vs 2.7 ± 3.6 mL/m(2); P=0.005, 2.5 ± 5.0 vs -1.3 ± 3.5%; P=0.03). Ramipril did not cause adverse events and was well tolerated.Ramipril is a well tolerated therapy, improves biventricular function in patients with rTOF and may have a particular role in patients with restrictive RV physiology. Larger, longer-term studies are needed to determine if ACE inhibitors can improve both ventricular remodelling and clinical outcomes. (97515585)." @default.
• W1785183744 created "2016-06-24" @default.
• W1785183744 creator A5000432967 @default.
• W1785183744 creator A5001906018 @default.
• W1785183744 creator A5007131365 @default.
• W1785183744 creator A5007799685 @default.
• W1785183744 creator A5011229512 @default.
• W1785183744 creator A5026341297 @default.
• W1785183744 creator A5037858868 @default.
• W1785183744 creator A5054951910 @default.
• W1785183744 creator A5063628238 @default.
• W1785183744 creator A5081550777 @default.
• W1785183744 creator A5084803985 @default.
• W1785183744 creator A5088583326 @default.
• W1785183744 creator A5091168003 @default.
• W1785183744 date "2012-02-01" @default.
• W1785183744 modified "2023-10-14" @default.
• W1785183744 title "Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation" @default.
• W1785183744 cites W180946569 @default.
• W1785183744 cites W1968298047 @default.
• W1785183744 cites W1968681455 @default.
• W1785183744 cites W1974659437 @default.
• W1785183744 cites W1975026061 @default.
• W1785183744 cites W1979882924 @default.
• W1785183744 cites W1979936993 @default.
• W1785183744 cites W1981884097 @default.
• W1785183744 cites W1993519137 @default.
• W1785183744 cites W1995097744 @default.
• W1785183744 cites W1995347073 @default.
• W1785183744 cites W2014078578 @default.
• W1785183744 cites W2018737077 @default.
• W1785183744 cites W2021044496 @default.
• W1785183744 cites W2022043412 @default.
• W1785183744 cites W2024894304 @default.
• W1785183744 cites W2031161073 @default.
• W1785183744 cites W2037342038 @default.
• W1785183744 cites W2041586231 @default.
• W1785183744 cites W2050415310 @default.
• W1785183744 cites W2057807206 @default.
• W1785183744 cites W2069263823 @default.
• W1785183744 cites W2073420794 @default.
• W1785183744 cites W2079280139 @default.
• W1785183744 cites W2087482310 @default.
• W1785183744 cites W2087890169 @default.
• W1785183744 cites W2089557483 @default.
• W1785183744 cites W2107528190 @default.
• W1785183744 cites W2108556871 @default.
• W1785183744 cites W2111736945 @default.
• W1785183744 cites W2112970658 @default.
• W1785183744 cites W2128179711 @default.
• W1785183744 cites W2147537697 @default.
• W1785183744 cites W2148813221 @default.
• W1785183744 cites W2151749028 @default.
• W1785183744 cites W2155014420 @default.
• W1785183744 cites W2161239206 @default.
• W1785183744 cites W2163346511 @default.
• W1785183744 cites W2167016594 @default.
• W1785183744 cites W2326354230 @default.
• W1785183744 cites W4327666125 @default.
• W1785183744 doi "https://doi.org/10.1016/j.ijcard.2010.09.057" @default.
• W1785183744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20970202" @default.
• W1785183744 hasPublicationYear "2012" @default.
• W1785183744 type Work @default.
• W1785183744 sameAs 1785183744 @default.
• W1785183744 citedByCount "90" @default.
• W1785183744 countsByYear W17851837442012 @default.
• W1785183744 countsByYear W17851837442013 @default.
• W1785183744 countsByYear W17851837442014 @default.
• W1785183744 countsByYear W17851837442015 @default.
• W1785183744 countsByYear W17851837442016 @default.
• W1785183744 countsByYear W17851837442017 @default.
• W1785183744 countsByYear W17851837442018 @default.
• W1785183744 countsByYear W17851837442019 @default.
• W1785183744 countsByYear W17851837442020 @default.
• W1785183744 countsByYear W17851837442021 @default.
• W1785183744 countsByYear W17851837442022 @default.
• W1785183744 countsByYear W17851837442023 @default.
• W1785183744 crossrefType "journal-article" @default.
• W1785183744 hasAuthorship W1785183744A5000432967 @default.
• W1785183744 hasAuthorship W1785183744A5001906018 @default.
• W1785183744 hasAuthorship W1785183744A5007131365 @default.
• W1785183744 hasAuthorship W1785183744A5007799685 @default.
• W1785183744 hasAuthorship W1785183744A5011229512 @default.
• W1785183744 hasAuthorship W1785183744A5026341297 @default.
• W1785183744 hasAuthorship W1785183744A5037858868 @default.
• W1785183744 hasAuthorship W1785183744A5054951910 @default.
• W1785183744 hasAuthorship W1785183744A5063628238 @default.
• W1785183744 hasAuthorship W1785183744A5081550777 @default.
• W1785183744 hasAuthorship W1785183744A5084803985 @default.
• W1785183744 hasAuthorship W1785183744A5088583326 @default.
• W1785183744 hasAuthorship W1785183744A5091168003 @default.
• W1785183744 hasConcept C126322002 @default.
• W1785183744 hasConcept C142724271 @default.
• W1785183744 hasConcept C164705383 @default.
• W1785183744 hasConcept C168563851 @default.
• W1785183744 hasConcept C203092338 @default.
• W1785183744 hasConcept C204787440 @default.
• W1785183744 hasConcept C27016395 @default.

• next