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- W1785191208 abstract "Summary 1.1:2-Benzanthracene and chrysene were carcinogenic, inducing sarcoma on subcutaneous injection. The former was stronger than the latter, having both a shorter induction time and a higher tumor yield. The significance of these results with regard to the relation of chemical-physical characteristics of hydrocarbons to their carcinogenicity is discussed. 2.1:2-Benzanthracene and chrysene injected together showed definite summation of carcinogenic effects if not actually a synergistic action. The tumor yield was greater than the sum of their individual tumor yields, despite the halving of the dose of each compound injected. This observation is significant, because it cannot be explained by the existing theories of inhibition or summation effects of carcinogenic compounds. 3.The carcinogenic effects of 1:2-benzanthracene and 1:2:5:6-dibenzanthracene injected together were not those of summation but apparently of inhibition. 4.The carcinogenic effects of 1:2:5:6-dibenzanthracene and 20-methylcholanthrene injected together were additive, although imperfectly so." @default.
- W1785191208 created "2016-06-24" @default.
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- W1785191208 date "1951-01-01" @default.
- W1785191208 modified "2023-09-23" @default.
- W1785191208 title "Summation and inhibition effects of weak and strong carcinogenic hydrocarbons: 1:2-benzanthracene, chrysene, 1:2:5:6-dibenzanthracene, and 20-methylcholanthrene." @default.
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