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• W178520596 abstract "Using a modified Boyden chamber assay, we have examined the effect of cyclic nucleotides on bovine aortic endothelial cell migration in vitro. Dibutyrl cyclic 3',5'-adenosine monophosphate (5 mM) inhibited endothelial cell random migration by 67% and inhibited fibronectin-induced chemotaxis by 75%. Agents which significantly stimulated adenylate cyclase activity in endothelial cell membranes were also effective inhibitors of endothelial cell migration. Timolol blocked both the isoproterenol-induced stimulation of adenylate cyclase and the ability of isoproterenol to inhibit endothelial cell migration. Caffeine and isoproterenol together had a greater inhibitory effect on endothelial cell motility than either alone. These data suggest that cAMP may modulate vascular endothelial cell migration in an inhibitory fashion." @default.
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• W178520596 date "1987-04-01" @default.
• W178520596 modified "2023-09-26" @default.
• W178520596 title "Cyclic 3?,5?-adenosine monophosphate modulates vascular endothelial cell migration" @default.
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• W178520596 doi "https://doi.org/10.1016/0309-1651(87)90089-0" @default.
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