FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1785315612> ?p ?o ?g. }

• W1785315612 endingPage "30" @default.
• W1785315612 startingPage "1" @default.
• W1785315612 abstract "We wanted to improve tendon healing by adding a growth factor. Bone Morphogenetic Proteins (BMPs) are well known to stimulate bone healing and bone formation. The local environment is of major importance for cell differentiation after a BMP has been added. Cartilage Derived Morphogenetic Proteins (CDMPs) -1, -2 and -3 (BMP 14, 13 and 12 or GDF 5, 6 and 7) form a subgroup in the BMP-family and are closely related to OP-1 (BMP 7). CDMP implants have been shown to induce bone and cartilage as well as tendon and ligament-like tissue. Our hypothesis has therefore been that if a BMP were added in a tendon environment, a tendon-like tissue would be induced.We have developed models in rats and rabbits where the Achilles tendon is transsected. To influence tendon healing, different BMPs (OP-1, CDMP-1. -2 and -3) were added, either on a collagen carrier, or as a local injection into the tendon defect. The tendons were evaluated by histology and mechanical testing at different time-points after transection.The results show that also when the mechanical environment would favour the formation of a tendon-like tissue, OP-1 reduced tendon strength in aid of bone formation. In contrast, CDMP-1, -2 and -3 had a beneficial effect upon tendon healing in rats. More callus tissue was produced than in controls, and strength and stiffness were improved, although minor amounts of bone and cartilage were detected in the tendon callus. Cartilage and bone formation sometimes occur normally during Achilles tendon healing in rats. In the rabbit model, where the healing situation is more similar to the clinical situation, the positive result with CDMP-2 was repeated. Moreover, in rabbits no bone or cartilage was found.The results suggest that conservative treatment of Achilles tendon ruptures with injection of a CDMP in combination with early rehabilitation might afford a good alternative to surgical treatment." @default.
• W1785315612 created "2016-06-24" @default.
• W1785315612 creator A5039934046 @default.
• W1785315612 date "2002-01-01" @default.
• W1785315612 modified "2023-09-27" @default.
• W1785315612 title "BMP treatment for improving tendon repair Studies on rat and rabbit Achilles tendons" @default.
• W1785315612 cites W115255336 @default.
• W1785315612 cites W1517038772 @default.
• W1785315612 cites W156099281 @default.
• W1785315612 cites W1921141222 @default.
• W1785315612 cites W1954636360 @default.
• W1785315612 cites W1966239116 @default.
• W1785315612 cites W1968742787 @default.
• W1785315612 cites W1968822620 @default.
• W1785315612 cites W1972401404 @default.
• W1785315612 cites W1972972562 @default.
• W1785315612 cites W1973308609 @default.
• W1785315612 cites W197452303 @default.
• W1785315612 cites W1976466736 @default.
• W1785315612 cites W1979232050 @default.
• W1785315612 cites W1981089517 @default.
• W1785315612 cites W1981949603 @default.
• W1785315612 cites W1984316480 @default.
• W1785315612 cites W1986469118 @default.
• W1785315612 cites W1988335958 @default.
• W1785315612 cites W1989477285 @default.
• W1785315612 cites W1989922873 @default.
• W1785315612 cites W1990409165 @default.
• W1785315612 cites W1992883394 @default.
• W1785315612 cites W1995728060 @default.
• W1785315612 cites W1997104142 @default.
• W1785315612 cites W1998047628 @default.
• W1785315612 cites W2007809259 @default.
• W1785315612 cites W2009675065 @default.
• W1785315612 cites W2012551642 @default.
• W1785315612 cites W2015994921 @default.
• W1785315612 cites W2020442367 @default.
• W1785315612 cites W2022976664 @default.
• W1785315612 cites W2027751122 @default.
• W1785315612 cites W2031400733 @default.
• W1785315612 cites W2035737996 @default.
• W1785315612 cites W2039375591 @default.
• W1785315612 cites W2040027102 @default.
• W1785315612 cites W2040493554 @default.
• W1785315612 cites W2048716845 @default.
• W1785315612 cites W2054831731 @default.
• W1785315612 cites W2055110202 @default.
• W1785315612 cites W2060288350 @default.
• W1785315612 cites W2063463470 @default.
• W1785315612 cites W2069673898 @default.
• W1785315612 cites W2072406684 @default.
• W1785315612 cites W2073630220 @default.
• W1785315612 cites W2080986448 @default.
• W1785315612 cites W2081519645 @default.
• W1785315612 cites W2083328254 @default.
• W1785315612 cites W2094714618 @default.
• W1785315612 cites W2097913938 @default.
• W1785315612 cites W2098822366 @default.
• W1785315612 cites W2101077474 @default.
• W1785315612 cites W2104271465 @default.
• W1785315612 cites W2105286627 @default.
• W1785315612 cites W2105944086 @default.
• W1785315612 cites W2109957926 @default.
• W1785315612 cites W2119981622 @default.
• W1785315612 cites W2121848695 @default.
• W1785315612 cites W2122246981 @default.
• W1785315612 cites W2122532291 @default.
• W1785315612 cites W2132030085 @default.
• W1785315612 cites W2136332052 @default.
• W1785315612 cites W2144208159 @default.
• W1785315612 cites W2158707966 @default.
• W1785315612 cites W2166829805 @default.
• W1785315612 cites W2234549232 @default.
• W1785315612 cites W2325792484 @default.
• W1785315612 cites W2409809974 @default.
• W1785315612 cites W2410041825 @default.
• W1785315612 cites W2982949029 @default.
• W1785315612 cites W2988868023 @default.
• W1785315612 doi "https://doi.org/10.1080/000164702760300006" @default.
• W1785315612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12640969" @default.
• W1785315612 hasPublicationYear "2002" @default.
• W1785315612 type Work @default.
• W1785315612 sameAs 1785315612 @default.
• W1785315612 citedByCount "11" @default.
• W1785315612 countsByYear W17853156122012 @default.
• W1785315612 countsByYear W17853156122014 @default.
• W1785315612 countsByYear W17853156122016 @default.
• W1785315612 countsByYear W17853156122022 @default.
• W1785315612 crossrefType "journal-article" @default.
• W1785315612 hasAuthorship W1785315612A5039934046 @default.
• W1785315612 hasBestOaLocation W17853156121 @default.
• W1785315612 hasConcept C105702510 @default.
• W1785315612 hasConcept C105795698 @default.
• W1785315612 hasConcept C141071460 @default.
• W1785315612 hasConcept C2779884254 @default.
• W1785315612 hasConcept C2780105995 @default.
• W1785315612 hasConcept C2780984734 @default.
• W1785315612 hasConcept C33923547 @default.

• next