Matches in SemOpenAlex for { <https://semopenalex.org/work/W1785735331> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1785735331 endingPage "81" @default.
- W1785735331 startingPage "77" @default.
- W1785735331 abstract "To determine the influence of the route of administration on the hormonal and lipemic responses to 17β-estradiol, 50 postmenopausal women were studied before and after various regimens of replacement therapy. The effects on plasma lipids and lipoproteins and on estrone and estradiol levels of the oral administration of micronized estradiol or estradiol valerate (2 mg/24 hours) were compared to those of percutaneously administered estradiol (3 mg/24 hours). These treatments were given during two cycles of 3 weeks separated by a 1-week interval. Circulating levels of estradiol and estrone increased significantly (p < 0.05) in all groups while follicle-stimulating hormone levels decreased significantly. The posttreatment estradiol/estrone ratio was significantly (p < 0.05) greater in the parenteral group (0.8 ± 0.1) than in both oral estrogen groups (0.3 ± 0.1 and 0.4 ± 0.1, respectively). Oral administration of estradiol resulted in a significant increase in triglycerides (20% to 44%, p < 0.05) and very low-density lipoprotein (VLDL) triglycerides (30% to 40%, p < 0.05) and a decrease in low-density lipoprotein cholesterol (14% to 17%, p < 0.05). In contrast, despite a substantial increase in serum estrogen levels, percutaneous estradiol induced a significant decrease in triglyceride (from 0.78 ± 0.04 to 0.67 ± 0.05 mmol/L, p < 0.001) and VLDL triglyceride (from 0.44 ± 0.16 to 0.35 ± 0.12 mmol/L p < 0.05) levels and no significant change in cholesterol levels. The increases of high-density lipoprotein cholesterol levels observed in the three groups were not significant. These data indicate that the route of administration modulates the metabolic and hormonal responses to estrogen therapy." @default.
- W1785735331 created "2016-06-24" @default.
- W1785735331 creator A5003921557 @default.
- W1785735331 creator A5020862274 @default.
- W1785735331 creator A5048383212 @default.
- W1785735331 date "1983-09-01" @default.
- W1785735331 modified "2023-09-26" @default.
- W1785735331 title "Differential lipemic and hormonal responses to oral and parenteral 17β-estradiol in postmenopausal women" @default.
- W1785735331 cites W158133105 @default.
- W1785735331 cites W1589136537 @default.
- W1785735331 cites W1968160189 @default.
- W1785735331 cites W1973624475 @default.
- W1785735331 cites W2018399973 @default.
- W1785735331 cites W2023471616 @default.
- W1785735331 cites W2032789452 @default.
- W1785735331 cites W2062694421 @default.
- W1785735331 cites W2101515693 @default.
- W1785735331 cites W2343848055 @default.
- W1785735331 cites W4235087192 @default.
- W1785735331 doi "https://doi.org/10.1016/0002-9378(83)90088-1" @default.
- W1785735331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6412553" @default.
- W1785735331 hasPublicationYear "1983" @default.
- W1785735331 type Work @default.
- W1785735331 sameAs 1785735331 @default.
- W1785735331 citedByCount "57" @default.
- W1785735331 countsByYear W17857353312016 @default.
- W1785735331 crossrefType "journal-article" @default.
- W1785735331 hasAuthorship W1785735331A5003921557 @default.
- W1785735331 hasAuthorship W1785735331A5020862274 @default.
- W1785735331 hasAuthorship W1785735331A5048383212 @default.
- W1785735331 hasConcept C126322002 @default.
- W1785735331 hasConcept C134018914 @default.
- W1785735331 hasConcept C2777164284 @default.
- W1785735331 hasConcept C2778001906 @default.
- W1785735331 hasConcept C2778163477 @default.
- W1785735331 hasConcept C2778620825 @default.
- W1785735331 hasConcept C2778656385 @default.
- W1785735331 hasConcept C2778913445 @default.
- W1785735331 hasConcept C2780072125 @default.
- W1785735331 hasConcept C62231903 @default.
- W1785735331 hasConcept C71315377 @default.
- W1785735331 hasConcept C71924100 @default.
- W1785735331 hasConcept C8243546 @default.
- W1785735331 hasConceptScore W1785735331C126322002 @default.
- W1785735331 hasConceptScore W1785735331C134018914 @default.
- W1785735331 hasConceptScore W1785735331C2777164284 @default.
- W1785735331 hasConceptScore W1785735331C2778001906 @default.
- W1785735331 hasConceptScore W1785735331C2778163477 @default.
- W1785735331 hasConceptScore W1785735331C2778620825 @default.
- W1785735331 hasConceptScore W1785735331C2778656385 @default.
- W1785735331 hasConceptScore W1785735331C2778913445 @default.
- W1785735331 hasConceptScore W1785735331C2780072125 @default.
- W1785735331 hasConceptScore W1785735331C62231903 @default.
- W1785735331 hasConceptScore W1785735331C71315377 @default.
- W1785735331 hasConceptScore W1785735331C71924100 @default.
- W1785735331 hasConceptScore W1785735331C8243546 @default.
- W1785735331 hasIssue "1" @default.
- W1785735331 hasLocation W17857353311 @default.
- W1785735331 hasLocation W17857353312 @default.
- W1785735331 hasOpenAccess W1785735331 @default.
- W1785735331 hasPrimaryLocation W17857353311 @default.
- W1785735331 hasRelatedWork W1785735331 @default.
- W1785735331 hasRelatedWork W1976602105 @default.
- W1785735331 hasRelatedWork W2072276648 @default.
- W1785735331 hasRelatedWork W2101821182 @default.
- W1785735331 hasRelatedWork W2130678710 @default.
- W1785735331 hasRelatedWork W2157000830 @default.
- W1785735331 hasRelatedWork W2157155183 @default.
- W1785735331 hasRelatedWork W2168803779 @default.
- W1785735331 hasRelatedWork W2318646559 @default.
- W1785735331 hasRelatedWork W2413861530 @default.
- W1785735331 hasVolume "147" @default.
- W1785735331 isParatext "false" @default.
- W1785735331 isRetracted "false" @default.
- W1785735331 magId "1785735331" @default.
- W1785735331 workType "article" @default.