FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1786572981> ?p ?o ?g. }

• W1786572981 endingPage "579" @default.
• W1786572981 startingPage "571" @default.
• W1786572981 abstract "In this work, we prepared a panel of monoclonal anti-idiotypic antibodies to ovine prolactin (oPRL) by the hybridoma technique. Among these antibodies, one anti-idotypic antibody (designated B7) was chosen for further characterization by a series of experiments. We first demonstrated that B7 behaved as a typical Ab2β based on a series of enzyme-linked immunosorbent assays. Subsequently, the results of a competitive receptor-binding assay confirmed that B7 could specifically bind to the prolactin receptor (PRLR) expressed on target cells. Finally, we examined its biological activities in CHO-PRLR and Nb2 cells and observed that B7 could activate Janus kinase 2-signal transducer and activator of transcription signalling in CHO-PRLR and Nb2 cells and induce BaF3 proliferation. The present study suggests that i) B7 can serve as a PRLR agonist or PRL mimic and has potential applications in regulating mammary gland development, milk production and maintenance of lactation in domestic animals and ii) B7 may be a biological reagent that can be used to explore the mechanism of PRLR-mediated intracellular signalling. Keywords: Prolactin; Anti-idotypic Antibody; Signal Transduction" @default.
• W1786572981 created "2016-06-24" @default.
• W1786572981 creator A5008432510 @default.
• W1786572981 creator A5036726873 @default.
• W1786572981 creator A5039820563 @default.
• W1786572981 creator A5076641041 @default.
• W1786572981 date "2016-02-24" @default.
• W1786572981 modified "2023-10-03" @default.
• W1786572981 title "Development of a Novel, Anti-idiotypic Monoclonal Anti-prolactin Antibody That Mimics the Physiological Functions of Prolactin" @default.
• W1786572981 cites W1488471698 @default.
• W1786572981 cites W1555657815 @default.
• W1786572981 cites W1566766802 @default.
• W1786572981 cites W1803382068 @default.
• W1786572981 cites W1977107368 @default.
• W1786572981 cites W1984302481 @default.
• W1786572981 cites W1989110312 @default.
• W1786572981 cites W1989290158 @default.
• W1786572981 cites W2007815440 @default.
• W1786572981 cites W2011573316 @default.
• W1786572981 cites W2030601224 @default.
• W1786572981 cites W2053183868 @default.
• W1786572981 cites W2055133913 @default.
• W1786572981 cites W2087629943 @default.
• W1786572981 cites W2113103296 @default.
• W1786572981 cites W2114093706 @default.
• W1786572981 cites W2151652151 @default.
• W1786572981 cites W2156582504 @default.
• W1786572981 cites W2160142575 @default.
• W1786572981 cites W2167988015 @default.
• W1786572981 cites W2415109814 @default.
• W1786572981 cites W98350484 @default.
• W1786572981 doi "https://doi.org/10.5713/ajas.15.0541" @default.
• W1786572981 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4782093" @default.
• W1786572981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26949959" @default.
• W1786572981 hasPublicationYear "2016" @default.
• W1786572981 type Work @default.
• W1786572981 sameAs 1786572981 @default.
• W1786572981 citedByCount "4" @default.
• W1786572981 countsByYear W17865729812017 @default.
• W1786572981 countsByYear W17865729812019 @default.
• W1786572981 countsByYear W17865729812020 @default.
• W1786572981 countsByYear W17865729812022 @default.
• W1786572981 crossrefType "journal-article" @default.
• W1786572981 hasAuthorship W1786572981A5008432510 @default.
• W1786572981 hasAuthorship W1786572981A5036726873 @default.
• W1786572981 hasAuthorship W1786572981A5039820563 @default.
• W1786572981 hasAuthorship W1786572981A5076641041 @default.
• W1786572981 hasBestOaLocation W17865729811 @default.
• W1786572981 hasConcept C112392421 @default.
• W1786572981 hasConcept C134018914 @default.
• W1786572981 hasConcept C153911025 @default.
• W1786572981 hasConcept C159654299 @default.
• W1786572981 hasConcept C170493617 @default.
• W1786572981 hasConcept C203014093 @default.
• W1786572981 hasConcept C2778938600 @default.
• W1786572981 hasConcept C2779064019 @default.
• W1786572981 hasConcept C2781031661 @default.
• W1786572981 hasConcept C32465701 @default.
• W1786572981 hasConcept C542903549 @default.
• W1786572981 hasConcept C55493867 @default.
• W1786572981 hasConcept C62478195 @default.
• W1786572981 hasConcept C71315377 @default.
• W1786572981 hasConcept C86803240 @default.
• W1786572981 hasConcept C88045685 @default.
• W1786572981 hasConcept C95444343 @default.
• W1786572981 hasConceptScore W1786572981C112392421 @default.
• W1786572981 hasConceptScore W1786572981C134018914 @default.
• W1786572981 hasConceptScore W1786572981C153911025 @default.
• W1786572981 hasConceptScore W1786572981C159654299 @default.
• W1786572981 hasConceptScore W1786572981C170493617 @default.
• W1786572981 hasConceptScore W1786572981C203014093 @default.
• W1786572981 hasConceptScore W1786572981C2778938600 @default.
• W1786572981 hasConceptScore W1786572981C2779064019 @default.
• W1786572981 hasConceptScore W1786572981C2781031661 @default.
• W1786572981 hasConceptScore W1786572981C32465701 @default.
• W1786572981 hasConceptScore W1786572981C542903549 @default.
• W1786572981 hasConceptScore W1786572981C55493867 @default.
• W1786572981 hasConceptScore W1786572981C62478195 @default.
• W1786572981 hasConceptScore W1786572981C71315377 @default.
• W1786572981 hasConceptScore W1786572981C86803240 @default.
• W1786572981 hasConceptScore W1786572981C88045685 @default.
• W1786572981 hasConceptScore W1786572981C95444343 @default.
• W1786572981 hasIssue "4" @default.
• W1786572981 hasLocation W17865729811 @default.
• W1786572981 hasLocation W17865729812 @default.
• W1786572981 hasLocation W17865729813 @default.
• W1786572981 hasLocation W17865729814 @default.
• W1786572981 hasLocation W17865729815 @default.
• W1786572981 hasOpenAccess W1786572981 @default.
• W1786572981 hasPrimaryLocation W17865729811 @default.
• W1786572981 hasRelatedWork W1506333309 @default.
• W1786572981 hasRelatedWork W1963919935 @default.
• W1786572981 hasRelatedWork W2058954970 @default.
• W1786572981 hasRelatedWork W2060761908 @default.
• W1786572981 hasRelatedWork W2063619316 @default.
• W1786572981 hasRelatedWork W2346421204 @default.
• W1786572981 hasRelatedWork W4233229186 @default.
• W1786572981 hasRelatedWork W4247681771 @default.

• next