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- W1786630863 abstract "Introduction: T helper lymphocytes are likely to play a pivotal role in directing disease development and progression in asthma. We recently described presence of α1 and α2 integrins on blood eosinophils and α2 on blood CD4 and CD8 T lymphocytes in chronic asthma. We hypothesize that collagen receptors: α1β1 and α2β1 integrins may play an important role in cell transmigration to the sites of asthmatic inflammation. Methods: We studied effects of functional active, mouse anti-human monoclonal antibodies against I-domain of α1 and α2 integrin subunit (Chemicon, USA) on eosinophil and lymphocyte transmigration through human extracellular matrix and collagen I coated cell culture inserts (Beckton Dickinson Falcon Cell Culture Inserts – 3 μm pore size). In 6 atopic asthmatics lymphocytes were separated from peripheral blood by gradient centrifugation and eosinophils by gradient centrifugation and negative magnetic separation (Vario MACS, Miltenyi Biotec). Results: None of the antibodies used influenced lymphocyte transmigration through human extracellular matrix and collagen I coated inserts. However, movement of peripheral blood eosinophils through human extracellular matrix was inhibited by both antibodies (% of inhibition: 30±26 for anti-α1, 25±24 for anti-α2 mAb). Anti-α2 mAb was also active on collagen I coated inserts (37 ± SD33); anti-α1 mAb was not effective. Conclusion: The α2β1 integrin is present on lymphocytes, but seems to play no role in lymphocyte infiltration. However, both α1β1 and α2β1 integrins might be important in eosinophil transmigration and support airway inflammation." @default.
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- W1786630863 date "2011-09-01" @default.
- W1786630863 modified "2023-10-15" @default.
- W1786630863 title "Inhibition of collagen receptors: α1β1 and α2β1 integrins, has no impact on lymphocytes, but decreases eosinophil transmigration through human extracellular matrix and collagen I coated inserts" @default.
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