Matches in SemOpenAlex for { <https://semopenalex.org/work/W1786787430> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W1786787430 endingPage "12" @default.
- W1786787430 startingPage "3703" @default.
- W1786787430 abstract "The heat shock proteins (HSPs) HSP70 and gp96 from necrotic tumour cells are considered to function as chaperones in presenting tumour antigens. We therefore studied HSP70 and immune cells in a transplantable carcinoma in the liver of rats after interstitial laser thermotherapy (ILT). Experiments were performed in Wistar FU rats using a dimethyl-hydrazine-induced adenocarcinoma implanted into the left lateral lobe of the liver. Rats were randomized to one of the following groups: a) ILT of tumour, b) sham ILT, or c) control. ILT was suboptimal and was performed at a steady-state temperature of 43 degrees C at the tumour margin for 30 minutes. Rats were killed 15 minutes, 5 hours, 10 hours, 15 hours or 12 days after treatment. Double immunohistochemistry was performed for HSP70 and ED1 macrophages or CD8 lymphocytes, and ELISA for serum concentrations of HSP70. After ILT, there was an increase of HSP70 immunoreactivity in tumours as compared to sham ILT. At the same time, tumour cells affected by ILT showed a shift of HSP70 from the cytoplasm to the nucleus with a peak at 10 hours. Few CD8-positive cells were found. There was an increase of tumour-infiltrating ED1 macrophages after ILT as compared to sham ILT at 10-15 hours after treatment. HSP70 was present in ED1 macrophages significantly more frequently after ILT than after sham ILT, and this was true both for HSP70 localized to the surface and the cytoplasm of the macrophage. There was a significant increase in serum HSP70 during the first 15 hours after ILT. In conclusion, laser thermotherapy resulted in increased HSP70 immunoreactivity within tumours and HSP70 shifts from cytoplasm to nucleus. Furthermore, it resulted in increased numbers of tumour-infiltrating macrophages and an increased presence of HSP70 in the membrane and cytoplasm of these macrophages." @default.
- W1786787430 created "2016-06-24" @default.
- W1786787430 creator A5007350174 @default.
- W1786787430 creator A5019072319 @default.
- W1786787430 creator A5028783017 @default.
- W1786787430 creator A5056312267 @default.
- W1786787430 creator A5064218855 @default.
- W1786787430 creator A5074107873 @default.
- W1786787430 date "2003-12-12" @default.
- W1786787430 modified "2023-09-26" @default.
- W1786787430 title "Heat shock protein 70 (HSP70) after laser thermotherapy of an adenocarcinoma transplanted into rat liver." @default.
- W1786787430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14666667" @default.
- W1786787430 hasPublicationYear "2003" @default.
- W1786787430 type Work @default.
- W1786787430 sameAs 1786787430 @default.
- W1786787430 citedByCount "10" @default.
- W1786787430 countsByYear W17867874302012 @default.
- W1786787430 countsByYear W17867874302014 @default.
- W1786787430 countsByYear W17867874302015 @default.
- W1786787430 countsByYear W17867874302023 @default.
- W1786787430 crossrefType "journal-article" @default.
- W1786787430 hasAuthorship W1786787430A5007350174 @default.
- W1786787430 hasAuthorship W1786787430A5019072319 @default.
- W1786787430 hasAuthorship W1786787430A5028783017 @default.
- W1786787430 hasAuthorship W1786787430A5056312267 @default.
- W1786787430 hasAuthorship W1786787430A5064218855 @default.
- W1786787430 hasAuthorship W1786787430A5074107873 @default.
- W1786787430 hasConcept C104317684 @default.
- W1786787430 hasConcept C121608353 @default.
- W1786787430 hasConcept C126322002 @default.
- W1786787430 hasConcept C142724271 @default.
- W1786787430 hasConcept C167672396 @default.
- W1786787430 hasConcept C203014093 @default.
- W1786787430 hasConcept C204232928 @default.
- W1786787430 hasConcept C205260736 @default.
- W1786787430 hasConcept C2781182431 @default.
- W1786787430 hasConcept C55493867 @default.
- W1786787430 hasConcept C68991219 @default.
- W1786787430 hasConcept C71924100 @default.
- W1786787430 hasConcept C86803240 @default.
- W1786787430 hasConcept C8891405 @default.
- W1786787430 hasConceptScore W1786787430C104317684 @default.
- W1786787430 hasConceptScore W1786787430C121608353 @default.
- W1786787430 hasConceptScore W1786787430C126322002 @default.
- W1786787430 hasConceptScore W1786787430C142724271 @default.
- W1786787430 hasConceptScore W1786787430C167672396 @default.
- W1786787430 hasConceptScore W1786787430C203014093 @default.
- W1786787430 hasConceptScore W1786787430C204232928 @default.
- W1786787430 hasConceptScore W1786787430C205260736 @default.
- W1786787430 hasConceptScore W1786787430C2781182431 @default.
- W1786787430 hasConceptScore W1786787430C55493867 @default.
- W1786787430 hasConceptScore W1786787430C68991219 @default.
- W1786787430 hasConceptScore W1786787430C71924100 @default.
- W1786787430 hasConceptScore W1786787430C86803240 @default.
- W1786787430 hasConceptScore W1786787430C8891405 @default.
- W1786787430 hasIssue "5A" @default.
- W1786787430 hasLocation W17867874301 @default.
- W1786787430 hasOpenAccess W1786787430 @default.
- W1786787430 hasPrimaryLocation W17867874301 @default.
- W1786787430 hasRelatedWork W1972998469 @default.
- W1786787430 hasRelatedWork W1984522005 @default.
- W1786787430 hasRelatedWork W2061871833 @default.
- W1786787430 hasRelatedWork W2322067318 @default.
- W1786787430 hasRelatedWork W2358855735 @default.
- W1786787430 hasRelatedWork W2411775713 @default.
- W1786787430 hasRelatedWork W2748291430 @default.
- W1786787430 hasRelatedWork W2999862739 @default.
- W1786787430 hasRelatedWork W4234833771 @default.
- W1786787430 hasRelatedWork W815541959 @default.
- W1786787430 hasVolume "23" @default.
- W1786787430 isParatext "false" @default.
- W1786787430 isRetracted "false" @default.
- W1786787430 magId "1786787430" @default.
- W1786787430 workType "article" @default.