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• W1786812680 startingPage "147" @default.
• W1786812680 abstract "Lysosomes are acidic organelles that are involved in cellular digestion by endocy- tosis, phagocytosis, and autophagy. They contain more than 50 hydrolases that are capable of degrading all macromolecules. There is accumulating evidence that lysosomal enzymes can provoke apoptotic cell death. This has important implications for cancer, where proapoptotic genes are mutated and antiapoptotic genes are often overexpressed leading to chemoresistance. Lysosomes play a dual role in cancer development depending on their subcellular localization. When they are located extracellularly they can promote invasion, angiogenesis, and metastasis. However, when they are located intracellularly they can trigger apoptosis by leaking into the cytosol. In this review, we examine the pathways by which lysosomes can evoke both apoptosis and tumorigenesis. Although cancer cells have defects in their apoptotic machinery, they can still undergo lysosomal cell death. We offer several strategies to explain how targeting lysosomes can serve as a putative model for the development of novel anticancer agents. Furthermore, we propose that lysosomal cell death is an effective treatment against apoptosis-resistant can- cer cells and thus holds great potential as a therapeutic strategy for circumventing apoptosis deficiency in tumors." @default.
• W1786812680 created "2016-06-24" @default.
• W1786812680 creator A5017013096 @default.
• W1786812680 date "2015-09-01" @default.
• W1786812680 modified "2023-09-26" @default.
• W1786812680 title "Role of lysosomes in cancer therapy" @default.
• W1786812680 cites W1014722970 @default.
• W1786812680 cites W109599821 @default.
• W1786812680 cites W1205458192 @default.
• W1786812680 cites W1481507356 @default.
• W1786812680 cites W1488080528 @default.
• W1786812680 cites W1497499629 @default.
• W1786812680 cites W1522763255 @default.
• W1786812680 cites W1540679038 @default.
• W1786812680 cites W1545184254 @default.
• W1786812680 cites W1545541064 @default.
• W1786812680 cites W1558922335 @default.
• W1786812680 cites W1576530886 @default.
• W1786812680 cites W1585483493 @default.
• W1786812680 cites W1598023718 @default.
• W1786812680 cites W1602167922 @default.
• W1786812680 cites W170240114 @default.
• W1786812680 cites W1826848231 @default.
• W1786812680 cites W1938785803 @default.
• W1786812680 cites W1964307104 @default.
• W1786812680 cites W1964475578 @default.
• W1786812680 cites W1969792769 @default.
• W1786812680 cites W1972708772 @default.
• W1786812680 cites W1975387938 @default.
• W1786812680 cites W1981152641 @default.
• W1786812680 cites W1984145308 @default.
• W1786812680 cites W1991858888 @default.
• W1786812680 cites W1992464436 @default.
• W1786812680 cites W1992900472 @default.
• W1786812680 cites W1996934444 @default.
• W1786812680 cites W2000227309 @default.
• W1786812680 cites W2001139215 @default.
• W1786812680 cites W2001724432 @default.
• W1786812680 cites W2005566561 @default.
• W1786812680 cites W2006456311 @default.
• W1786812680 cites W2007301017 @default.
• W1786812680 cites W2009962397 @default.
• W1786812680 cites W2015015357 @default.
• W1786812680 cites W2016394200 @default.
• W1786812680 cites W2017593971 @default.
• W1786812680 cites W2018692481 @default.
• W1786812680 cites W2019363409 @default.
• W1786812680 cites W2019681593 @default.
• W1786812680 cites W2022210920 @default.
• W1786812680 cites W2024532487 @default.
• W1786812680 cites W2025820424 @default.
• W1786812680 cites W2026564047 @default.
• W1786812680 cites W2027595376 @default.
• W1786812680 cites W2030410023 @default.
• W1786812680 cites W2031219611 @default.
• W1786812680 cites W2033374599 @default.
• W1786812680 cites W2034166623 @default.
• W1786812680 cites W2034530432 @default.
• W1786812680 cites W2037283275 @default.
• W1786812680 cites W2037827452 @default.
• W1786812680 cites W2040340572 @default.
• W1786812680 cites W2041022386 @default.
• W1786812680 cites W2041973584 @default.
• W1786812680 cites W2042150510 @default.
• W1786812680 cites W2042406691 @default.
• W1786812680 cites W2042710439 @default.
• W1786812680 cites W2043344837 @default.
• W1786812680 cites W2044247344 @default.
• W1786812680 cites W2044256586 @default.
• W1786812680 cites W2045563337 @default.
• W1786812680 cites W2046205790 @default.
• W1786812680 cites W2046658642 @default.
• W1786812680 cites W2049422105 @default.
• W1786812680 cites W2049644040 @default.
• W1786812680 cites W2050750382 @default.
• W1786812680 cites W2051433821 @default.
• W1786812680 cites W2051945714 @default.
• W1786812680 cites W2053305234 @default.
• W1786812680 cites W2054107351 @default.
• W1786812680 cites W2061450777 @default.
• W1786812680 cites W2062031125 @default.
• W1786812680 cites W2066052096 @default.
• W1786812680 cites W2069979727 @default.
• W1786812680 cites W2073788301 @default.
• W1786812680 cites W2076296181 @default.
• W1786812680 cites W2077727884 @default.
• W1786812680 cites W2078689358 @default.
• W1786812680 cites W2079226222 @default.
• W1786812680 cites W2081055723 @default.
• W1786812680 cites W2081105252 @default.
• W1786812680 cites W2086922935 @default.
• W1786812680 cites W2088736593 @default.
• W1786812680 cites W2089038715 @default.
• W1786812680 cites W2089627345 @default.
• W1786812680 cites W2090985686 @default.
• W1786812680 cites W2093390763 @default.
• W1786812680 cites W2096535122 @default.
• W1786812680 cites W2097619603 @default.

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