Matches in SemOpenAlex for { <https://semopenalex.org/work/W1786874785> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1786874785 endingPage "88" @default.
- W1786874785 startingPage "1679" @default.
- W1786874785 abstract "To evaluate radiometal-labeled humanized BrE-3 (huBrE-3) monoclonal antibody as a radioimmunolocalization and therapeutic agent in breast cancer patients, tumor localization, pharmacokinetics, radiation dosimetry, and immunogenicity of (111)In-labeled combined 1-p-isothiocyanatobenzyl 3-methyl- and 1-p-isothiocyanatobenzyl 4-methyldiethylenetriamine pentaacetic acid (MX-DTPA) huBrE-3 were studied. Seven women with BrE-3 antigen-positive, metastatic breast carcinoma underwent (111)In huBrE-3 infusion (5 mCi; 50 mg), followed by serial gamma camera imaging and plasma sampling. Region of interest analysis of images was used to make radiation absorbed dose estimates for (111)In huBrE-3. Data were extrapolated to 90Y huBrE-3. Human anti-human antibody (HAHA) response was measured in serum samples obtained up to 3 months after infusion. Patients tolerated infusions well. Seventy-six percent of 105 known sites of disease were identified on planar and single-photon emission computed tomography scans. For six of seven patients, a biexponential model fit the plasma time-activity curve best with an average T1/2alpha=10.6+/-8.5 (SD) h and average T1/2beta=114.2+/-39.2 h. Radiation absorbed dose estimates for (111)In huBrE-3 for whole body averaged 0.53+/-.08 rads/mCi. Dose estimates for 90Y huBrE-3 for marrow averaged 8.4+/-11.9 rads/mCi, and for tumors, 70+/-31.5 rads/mCi. Liver radioactivity uptake averaged 19.7+/-8.8% injected dose at 24 h after infusion, translating into an average radiation absorbed dose 21.1+/-12 rads/90Y mCi administered. Only one of seven patients demonstrated a low level of HAHA response. Although the plasma half-lives are longer and marrow dose higher for radiolabeled huBrE-3 compared with the murine construct, the excellent tumor localization, good tumor dosimetry, and low immunogenicity support the use of 90Y-huBrE-3 antibody for radioimmunotherapy of breast cancer." @default.
- W1786874785 created "2016-06-24" @default.
- W1786874785 creator A5011070099 @default.
- W1786874785 creator A5011447518 @default.
- W1786874785 creator A5014151044 @default.
- W1786874785 creator A5020981900 @default.
- W1786874785 creator A5021752290 @default.
- W1786874785 creator A5028403692 @default.
- W1786874785 creator A5029672918 @default.
- W1786874785 creator A5035080887 @default.
- W1786874785 creator A5070492575 @default.
- W1786874785 creator A5073562498 @default.
- W1786874785 date "1998-07-01" @default.
- W1786874785 modified "2023-10-03" @default.
- W1786874785 title "Initial clinical evaluation of radiolabeled MX-DTPA humanized BrE-3 antibody in patients with advanced breast cancer." @default.
- W1786874785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9676842" @default.
- W1786874785 hasPublicationYear "1998" @default.
- W1786874785 type Work @default.
- W1786874785 sameAs 1786874785 @default.
- W1786874785 citedByCount "15" @default.
- W1786874785 countsByYear W17868747852015 @default.
- W1786874785 countsByYear W17868747852016 @default.
- W1786874785 countsByYear W17868747852018 @default.
- W1786874785 countsByYear W17868747852020 @default.
- W1786874785 countsByYear W17868747852022 @default.
- W1786874785 countsByYear W17868747852023 @default.
- W1786874785 crossrefType "journal-article" @default.
- W1786874785 hasAuthorship W1786874785A5011070099 @default.
- W1786874785 hasAuthorship W1786874785A5011447518 @default.
- W1786874785 hasAuthorship W1786874785A5014151044 @default.
- W1786874785 hasAuthorship W1786874785A5020981900 @default.
- W1786874785 hasAuthorship W1786874785A5021752290 @default.
- W1786874785 hasAuthorship W1786874785A5028403692 @default.
- W1786874785 hasAuthorship W1786874785A5029672918 @default.
- W1786874785 hasAuthorship W1786874785A5035080887 @default.
- W1786874785 hasAuthorship W1786874785A5070492575 @default.
- W1786874785 hasAuthorship W1786874785A5073562498 @default.
- W1786874785 hasConcept C112705442 @default.
- W1786874785 hasConcept C121608353 @default.
- W1786874785 hasConcept C126322002 @default.
- W1786874785 hasConcept C151337348 @default.
- W1786874785 hasConcept C159654299 @default.
- W1786874785 hasConcept C203014093 @default.
- W1786874785 hasConcept C2776146153 @default.
- W1786874785 hasConcept C2780868878 @default.
- W1786874785 hasConcept C2989005 @default.
- W1786874785 hasConcept C509974204 @default.
- W1786874785 hasConcept C530470458 @default.
- W1786874785 hasConcept C542903549 @default.
- W1786874785 hasConcept C71924100 @default.
- W1786874785 hasConcept C75088862 @default.
- W1786874785 hasConceptScore W1786874785C112705442 @default.
- W1786874785 hasConceptScore W1786874785C121608353 @default.
- W1786874785 hasConceptScore W1786874785C126322002 @default.
- W1786874785 hasConceptScore W1786874785C151337348 @default.
- W1786874785 hasConceptScore W1786874785C159654299 @default.
- W1786874785 hasConceptScore W1786874785C203014093 @default.
- W1786874785 hasConceptScore W1786874785C2776146153 @default.
- W1786874785 hasConceptScore W1786874785C2780868878 @default.
- W1786874785 hasConceptScore W1786874785C2989005 @default.
- W1786874785 hasConceptScore W1786874785C509974204 @default.
- W1786874785 hasConceptScore W1786874785C530470458 @default.
- W1786874785 hasConceptScore W1786874785C542903549 @default.
- W1786874785 hasConceptScore W1786874785C71924100 @default.
- W1786874785 hasConceptScore W1786874785C75088862 @default.
- W1786874785 hasIssue "7" @default.
- W1786874785 hasLocation W17868747851 @default.
- W1786874785 hasOpenAccess W1786874785 @default.
- W1786874785 hasPrimaryLocation W17868747851 @default.
- W1786874785 hasRelatedWork W1786874785 @default.
- W1786874785 hasRelatedWork W1923038941 @default.
- W1786874785 hasRelatedWork W1970641137 @default.
- W1786874785 hasRelatedWork W2087631306 @default.
- W1786874785 hasRelatedWork W2108213903 @default.
- W1786874785 hasRelatedWork W2141949865 @default.
- W1786874785 hasRelatedWork W2188221592 @default.
- W1786874785 hasRelatedWork W2345875835 @default.
- W1786874785 hasRelatedWork W4226448837 @default.
- W1786874785 hasRelatedWork W2186356445 @default.
- W1786874785 hasVolume "4" @default.
- W1786874785 isParatext "false" @default.
- W1786874785 isRetracted "false" @default.
- W1786874785 magId "1786874785" @default.
- W1786874785 workType "article" @default.