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- W178692011 abstract "In 2006 there were 60,000 new cases of cutaneous melanoma in the European Union and 13,000 deaths (www.europeancancerleagues. org). Currently available systemic treatment options for metastatic melanoma, including both cytotoxic and immunologic therapies, produce low rates of response and have modest survival impact. Therefore, there is an urgent need for effective novel therapies. Molecularly targeted treatments have demonstrated efficacy in certain cancers e.g. in HER2- positive breast cancer and in chronic myeloid leukaemia. Several pathways are currently being investigated as potential molecular targets in melanoma. The best studied is BRAF which is frequently mutated in melanoma. A multi tyrosine kinase inhibitor, sorafenib, which targets BRAF, has shown promising activity in preclinical studies and is currently being tested in combination with chemotherapy in patients with metastatic disease. In addition to BRAF, therapies which target other components of the Raf/Ras/MAPK pathway are being investigated. Other novel targets currently being investigated include the PI3/AKT pathway, tyrosine kinases, angiogenesis, poly (ADP ribose) polymerases, survivin and heat shock protein 90. Progress on preclinical and clinical evaluation of these novel targets in melanoma will be reviewed." @default.
- W178692011 created "2016-06-24" @default.
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- W178692011 creator A5091044927 @default.
- W178692011 date "2010-01-01" @default.
- W178692011 modified "2023-09-24" @default.
- W178692011 title "Prospects for non-immunological molecular therapeutics in melanoma." @default.
- W178692011 cites W1571264139 @default.
- W178692011 cites W1829794674 @default.
- W178692011 cites W1870720170 @default.
- W178692011 cites W1877440701 @default.
- W178692011 cites W1934287581 @default.
- W178692011 cites W1970700441 @default.
- W178692011 cites W1971282686 @default.
- W178692011 cites W1973966923 @default.
- W178692011 cites W1977979223 @default.
- W178692011 cites W1980431726 @default.
- W178692011 cites W1985036347 @default.
- W178692011 cites W1985068997 @default.
- W178692011 cites W1987407561 @default.
- W178692011 cites W1987409389 @default.
- W178692011 cites W1988219667 @default.
- W178692011 cites W1988620734 @default.
- W178692011 cites W1988698939 @default.
- W178692011 cites W1991196199 @default.
- W178692011 cites W1991541715 @default.
- W178692011 cites W1996112634 @default.
- W178692011 cites W1997928510 @default.
- W178692011 cites W1999198216 @default.
- W178692011 cites W2003973314 @default.
- W178692011 cites W2004792969 @default.
- W178692011 cites W2006808266 @default.
- W178692011 cites W2006850592 @default.
- W178692011 cites W2007345690 @default.
- W178692011 cites W2008677826 @default.
- W178692011 cites W2010980929 @default.
- W178692011 cites W2012026523 @default.
- W178692011 cites W2012701739 @default.
- W178692011 cites W2022952582 @default.
- W178692011 cites W2024262880 @default.
- W178692011 cites W2025486703 @default.
- W178692011 cites W2027857593 @default.
- W178692011 cites W2028138723 @default.
- W178692011 cites W2030443648 @default.
- W178692011 cites W2031111848 @default.
- W178692011 cites W2031718947 @default.
- W178692011 cites W2032751670 @default.
- W178692011 cites W2034048944 @default.
- W178692011 cites W2034516953 @default.
- W178692011 cites W2036500143 @default.
- W178692011 cites W2040189554 @default.
- W178692011 cites W2047067305 @default.
- W178692011 cites W2052370726 @default.
- W178692011 cites W2055846628 @default.
- W178692011 cites W2059148084 @default.
- W178692011 cites W2060317877 @default.
- W178692011 cites W2060809474 @default.
- W178692011 cites W2062289724 @default.
- W178692011 cites W2065392301 @default.
- W178692011 cites W2066179587 @default.
- W178692011 cites W2068944371 @default.
- W178692011 cites W2069023201 @default.
- W178692011 cites W2070396671 @default.
- W178692011 cites W2072568732 @default.
- W178692011 cites W2075650416 @default.
- W178692011 cites W2075786845 @default.
- W178692011 cites W2078519247 @default.
- W178692011 cites W2080313922 @default.
- W178692011 cites W2080483074 @default.
- W178692011 cites W2084060660 @default.
- W178692011 cites W2087012714 @default.
- W178692011 cites W2089168156 @default.
- W178692011 cites W2090398284 @default.
- W178692011 cites W2096814137 @default.
- W178692011 cites W2097373408 @default.
- W178692011 cites W2098587255 @default.
- W178692011 cites W2098844933 @default.
- W178692011 cites W2100677570 @default.
- W178692011 cites W2102820712 @default.
- W178692011 cites W2103027517 @default.
- W178692011 cites W2103786597 @default.
- W178692011 cites W2107077893 @default.
- W178692011 cites W2107417489 @default.
- W178692011 cites W2109545153 @default.
- W178692011 cites W2111888201 @default.
- W178692011 cites W2114024312 @default.
- W178692011 cites W2115851907 @default.
- W178692011 cites W2116725504 @default.
- W178692011 cites W2117263216 @default.
- W178692011 cites W2120807471 @default.
- W178692011 cites W2121356082 @default.
- W178692011 cites W2127120957 @default.
- W178692011 cites W2129318139 @default.
- W178692011 cites W2129683402 @default.
- W178692011 cites W2131384028 @default.