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- W1787089416 abstract "Epstein–Barr virus (EBV) infects 95% of the adult population and is the cause of infectious mononucleosis. It is also associated with 1% of cancers worldwide, such as nasopharyngeal carcinoma, Hodgkin's lymphoma and Burkitt's lymphoma. Human and cancer genetic studies are now major forces determining gene variants associated with many cancers, including nasopharyngeal carcinoma and Hodgkin's lymphoma. Host genetics is also important in infectious disease; however, there have been no large-scale efforts towards understanding the contribution that human genetic variation plays in primary EBV infection and latency. This review covers 25 years of studies into host genetic susceptibility to EBV infection and disease, from candidate gene studies, to the first genome-wide association study of EBV antibody response, and an EBV-status stratified genome-wide association study of Hodgkin's lymphoma. Although many genes are implicated in EBV-related disease, studies are often small, not replicated or followed up in a different disease. Larger, appropriately powered genomic studies to understand the host response to EBV will be needed to move our understanding of the biology of EBV infection beyond the handful of genes currently identified. Fifty years since the discovery of EBV and its identification as a human oncogenic virus, a glimpse of the future is shown by the first whole-genome and whole-exome studies, revealing new human genes at the heart of the host–EBV interaction. © 2014 The Authors. Reviews in Medical Virology published by John Wiley & Sons Ltd." @default.
- W1787089416 created "2016-06-24" @default.
- W1787089416 creator A5018934746 @default.
- W1787089416 creator A5067304304 @default.
- W1787089416 date "2014-11-27" @default.
- W1787089416 modified "2023-10-13" @default.
- W1787089416 title "Host genetics of Epstein–Barr virus infection, latency and disease" @default.
- W1787089416 cites W1042756630 @default.
- W1787089416 cites W139693862 @default.
- W1787089416 cites W1491667274 @default.
- W1787089416 cites W1518299472 @default.
- W1787089416 cites W1531490664 @default.
- W1787089416 cites W1848384264 @default.
- W1787089416 cites W1964550750 @default.
- W1787089416 cites W1967587135 @default.
- W1787089416 cites W1973215894 @default.
- W1787089416 cites W1974696705 @default.
- W1787089416 cites W1976111921 @default.
- W1787089416 cites W1979954542 @default.
- W1787089416 cites W1983386156 @default.
- W1787089416 cites W1983519619 @default.
- W1787089416 cites W1983944193 @default.
- W1787089416 cites W1985739089 @default.
- W1787089416 cites W1987160572 @default.
- W1787089416 cites W1989065947 @default.
- W1787089416 cites W1989733951 @default.
- W1787089416 cites W1991369877 @default.
- W1787089416 cites W1994759297 @default.
- W1787089416 cites W1994939326 @default.
- W1787089416 cites W1997347525 @default.
- W1787089416 cites W1998233030 @default.
- W1787089416 cites W1999695678 @default.
- W1787089416 cites W1999760331 @default.
- W1787089416 cites W2000789715 @default.
- W1787089416 cites W2002223549 @default.
- W1787089416 cites W2002707039 @default.
- W1787089416 cites W2005863787 @default.
- W1787089416 cites W2007021820 @default.
- W1787089416 cites W2009716709 @default.
- W1787089416 cites W2011950445 @default.
- W1787089416 cites W2012843549 @default.
- W1787089416 cites W2016666789 @default.
- W1787089416 cites W2018313719 @default.
- W1787089416 cites W2019044913 @default.
- W1787089416 cites W2019990122 @default.
- W1787089416 cites W2021702296 @default.
- W1787089416 cites W2026444780 @default.
- W1787089416 cites W2029491958 @default.
- W1787089416 cites W2030437588 @default.
- W1787089416 cites W2035667505 @default.
- W1787089416 cites W2036651650 @default.
- W1787089416 cites W2036676099 @default.
- W1787089416 cites W2039697985 @default.
- W1787089416 cites W2040558052 @default.
- W1787089416 cites W2040591401 @default.
- W1787089416 cites W2043433501 @default.
- W1787089416 cites W2045061666 @default.
- W1787089416 cites W2047301656 @default.
- W1787089416 cites W2055420466 @default.
- W1787089416 cites W2061491636 @default.
- W1787089416 cites W2064270136 @default.
- W1787089416 cites W2064869967 @default.
- W1787089416 cites W2065072425 @default.
- W1787089416 cites W2066669827 @default.
- W1787089416 cites W2073631928 @default.
- W1787089416 cites W2079845188 @default.
- W1787089416 cites W2080077971 @default.
- W1787089416 cites W2081186474 @default.
- W1787089416 cites W2085536915 @default.
- W1787089416 cites W2086948609 @default.
- W1787089416 cites W2092945250 @default.
- W1787089416 cites W2094197540 @default.
- W1787089416 cites W2096222118 @default.
- W1787089416 cites W2097903730 @default.
- W1787089416 cites W2103205585 @default.
- W1787089416 cites W2105385011 @default.
- W1787089416 cites W2105924489 @default.
- W1787089416 cites W2112510577 @default.
- W1787089416 cites W2114356279 @default.
- W1787089416 cites W2114828231 @default.
- W1787089416 cites W2114890741 @default.
- W1787089416 cites W2115806830 @default.
- W1787089416 cites W2122846177 @default.
- W1787089416 cites W2128395466 @default.
- W1787089416 cites W2132229447 @default.
- W1787089416 cites W2135158821 @default.
- W1787089416 cites W2137046848 @default.
- W1787089416 cites W2137462480 @default.
- W1787089416 cites W2140481064 @default.
- W1787089416 cites W2144769790 @default.
- W1787089416 cites W2146587137 @default.
- W1787089416 cites W2149024057 @default.
- W1787089416 cites W2149054391 @default.
- W1787089416 cites W2150040425 @default.
- W1787089416 cites W2152745352 @default.
- W1787089416 cites W2153525179 @default.
- W1787089416 cites W2154463582 @default.
- W1787089416 cites W2154910889 @default.