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- W1787280178 abstract "We synthesized two hydroquinone-tetraethylene glycol conjugates (HQ-TGs) and investigated their logP, photophysical stability, and redox chemical stability. HQ-TGs are a little more hydrophilic than hydroquinone (HQ) and show an enhanced photophysical and redox chemical stability compared with HQ. In addition we studied the effect of HQ-TGs on cell viability and on zebrafish pigmentation. MTT assay in HF-16 cells showed HQ-TGs are less cytotoxic than HQ. The phenotype-based image analysis of zebrafish larvae suggests that HQ-TGs suppress the pigmentation of zebrafish in a dose-dependent manner. The comparative experiments on stability, cytotoxicity, and zebrafish pigmentation between HQ and HQ-TGs suggest that mono tetraethylene glycol-functionalization of HQ is an alternative solution to overcome the adverse effect of HQ." @default.
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- W1787280178 date "2016-01-01" @default.
- W1787280178 modified "2023-09-24" @default.
- W1787280178 title "Regulatory effect of hydroquinone–tetraethylene glycol conjugates on zebrafish pigmentation" @default.
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- W1787280178 doi "https://doi.org/10.1016/j.bmcl.2015.09.059" @default.
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