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- W178739905 abstract "Parental (CBA-T6T6) cells are infected into (DS x CBA-T6T6) F/sub 1/ hybrid mice following varying doses of irradiation. Proliferation of erythropoietic cells was assayed by /sup 59/Fe uptake in the spleen and that of alloantigen-sensitive units (AASU) by 5-iodo-2'-deoxyuridine-/sup 125/I uptake. Erythropoietic differentiation of parental bone marrow cells was suppressed when the cells were injected with parental lymph node cells, and there were inverse relationships between the proliferation of erythroid cells and that of AASU. The change in the erythropoietic microenvironment seemed to have a more important role than the humoral erythropoiesis stimulating factor, because the erythropoiesis remained suppressed when the mouse was joined in parabiosis with another mouse in which erythropoesis was not as suppressed. With regard to the change in the local environment, the activating process of AASU was essential, not the activated AASU per se or some secretion of activated AASU. Evidence favoring this interpretation is: 1) Re-irradiation (830 rads) of the host abolished the suppressive effect of the previously injected, activated lymph node cells. 2) Erythropoietic differentiation of the marrow cells mixed with activated AASU was not suppressed when the cells were injected into irradiated CBA-T6T6 mice. (auth)" @default.
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- W178739905 date "1973-01-01" @default.
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- W178739905 title "Suppression of erythropoiesis by simultaneous proliferation of alloantigen-sensitive units." @default.
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