Matches in SemOpenAlex for { <https://semopenalex.org/work/W1787517352> ?p ?o ?g. }
- W1787517352 abstract "Soft tissue sarcomas (STSs) are rare malignant tumors, of which 3/4 are high-grade and 1/3 metastasize. For optimal management, STSs should be treated at multidisciplinary sarcoma centers. Study I demonstrated that simple referral guidelines, an open-access outpatient clinic and repeated educative measures to raise sarcoma awareness result in successful referral of untouched STSs to sarcoma center. Further, for each malignant tumor, 3 benign tumors were referred. Study II showed that though small STSs in general have a good prognosis, tumors with either of the risk factors necrosis or intratumoral vascular invasion had a 3-fold increased risk and STSs with both risk factors had an 11-fold increased risk of metastases. Study III describes changing clinical presentation of secondary angiosarcoma after breast cancer treatment; from late tumors in edematous arms, after median 11 years, to early tumors in the irradiated fields after median 7 years. Study IV report that secondary angiosarcomas on the thoracic wall are difficult to treat; the recurrence rate is high also after surgery with R0 margins and the prognosis dismal. Study V addressed differences in gene expression profiles between primary and secondary angiosarcomas. In secondary angiosarcomas RET, KIT and FLT4 within the receptor protein tyrosine kinase pathway, are significantly up-regulated. In summary, these studies show that high referral rates of STSs to a sarcoma center are possible to achieve, that small STSs with necrosis and vascular invasion had high risk of metastases, that the clinical presentation of secondary angiosarcomas has changed, that these tumors have high recurrence rates, and that up-regulation of the receptor protein tyrosine kinase pathway is common. (Less)" @default.
- W1787517352 created "2016-06-24" @default.
- W1787517352 creator A5039822866 @default.
- W1787517352 date "2013-01-01" @default.
- W1787517352 modified "2023-09-25" @default.
- W1787517352 title "Clinical and Biological Patterns in Soft Tissue Sarcoma" @default.
- W1787517352 cites W141370195 @default.
- W1787517352 cites W14647259 @default.
- W1787517352 cites W1482401268 @default.
- W1787517352 cites W1489202311 @default.
- W1787517352 cites W1559201260 @default.
- W1787517352 cites W169865300 @default.
- W1787517352 cites W1822314351 @default.
- W1787517352 cites W1831255489 @default.
- W1787517352 cites W1964939572 @default.
- W1787517352 cites W1965254413 @default.
- W1787517352 cites W1967806981 @default.
- W1787517352 cites W1968231628 @default.
- W1787517352 cites W1975303234 @default.
- W1787517352 cites W1979122323 @default.
- W1787517352 cites W1982255242 @default.
- W1787517352 cites W1983206829 @default.
- W1787517352 cites W1985116537 @default.
- W1787517352 cites W1989102106 @default.
- W1787517352 cites W1989916266 @default.
- W1787517352 cites W1990942642 @default.
- W1787517352 cites W1991038269 @default.
- W1787517352 cites W1992618206 @default.
- W1787517352 cites W1993432154 @default.
- W1787517352 cites W2003045926 @default.
- W1787517352 cites W2004036816 @default.
- W1787517352 cites W2010408856 @default.
- W1787517352 cites W2013162816 @default.
- W1787517352 cites W2015397617 @default.
- W1787517352 cites W2018153447 @default.
- W1787517352 cites W2020637497 @default.
- W1787517352 cites W2021151003 @default.
- W1787517352 cites W2028786260 @default.
- W1787517352 cites W2029893245 @default.
- W1787517352 cites W2030537668 @default.
- W1787517352 cites W2031270559 @default.
- W1787517352 cites W2032504112 @default.
- W1787517352 cites W2042526408 @default.
- W1787517352 cites W2045769280 @default.
- W1787517352 cites W2048758442 @default.
- W1787517352 cites W2051424864 @default.
- W1787517352 cites W2056721666 @default.
- W1787517352 cites W2061192590 @default.
- W1787517352 cites W2061368365 @default.
- W1787517352 cites W2062541316 @default.
- W1787517352 cites W2062608332 @default.
- W1787517352 cites W2064841975 @default.
- W1787517352 cites W2067787818 @default.
- W1787517352 cites W2068334943 @default.
- W1787517352 cites W2068822945 @default.
- W1787517352 cites W2072825648 @default.
- W1787517352 cites W2075899304 @default.
- W1787517352 cites W2078290313 @default.
- W1787517352 cites W2081269452 @default.
- W1787517352 cites W2088088119 @default.
- W1787517352 cites W2089152564 @default.
- W1787517352 cites W2089755974 @default.
- W1787517352 cites W2090806455 @default.
- W1787517352 cites W2094532843 @default.
- W1787517352 cites W2096150627 @default.
- W1787517352 cites W2096663717 @default.
- W1787517352 cites W2097172506 @default.
- W1787517352 cites W2100140003 @default.
- W1787517352 cites W2102945172 @default.
- W1787517352 cites W2103157878 @default.
- W1787517352 cites W2104213181 @default.
- W1787517352 cites W2107960986 @default.
- W1787517352 cites W2109740762 @default.
- W1787517352 cites W2116555643 @default.
- W1787517352 cites W2122528994 @default.
- W1787517352 cites W2127428399 @default.
- W1787517352 cites W2127570683 @default.
- W1787517352 cites W2129846590 @default.
- W1787517352 cites W2131756199 @default.
- W1787517352 cites W2136482853 @default.
- W1787517352 cites W2137076367 @default.
- W1787517352 cites W2137800448 @default.
- W1787517352 cites W2139131750 @default.
- W1787517352 cites W2140128064 @default.
- W1787517352 cites W2141348613 @default.
- W1787517352 cites W2141517903 @default.
- W1787517352 cites W2144530818 @default.
- W1787517352 cites W2144691565 @default.
- W1787517352 cites W2147449048 @default.
- W1787517352 cites W2156440431 @default.
- W1787517352 cites W2157795344 @default.
- W1787517352 cites W2157838823 @default.
- W1787517352 cites W2158217645 @default.
- W1787517352 cites W2161032069 @default.
- W1787517352 cites W2162180131 @default.
- W1787517352 cites W2178716779 @default.
- W1787517352 cites W2334258622 @default.
- W1787517352 cites W2397094642 @default.
- W1787517352 cites W2397507603 @default.
- W1787517352 cites W2400985801 @default.