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- W1787900469 abstract "Two years after the isolation of the first AIDS virus in 1983 (Barre-Sinoussi et al. 1983), a simian virus inducing a similar pathology was described in rhesus monkeys in captivity (Letvin et al. 1985). Apparently healthy individuals living in Senegal had antibodies that reacted better with the antigens of the simian virus than with those from the human virus (Barin et al. 1985). At the same period, two patients originating from West Africa were hospitalized in France and in Portugal with typical symptoms of AIDS, whereas their serology was negative for the human virus now called HIV-1. The second virus causing AIDS was isolated in 1986 (Clavel et al. 1986). It was then described in various countries of West Africa, and was later called Human immunodeficiency virus type 2 (HIV-2) (BrunVezinet et al. 1987; Clavel et al. 1987). It is classified in the Retroviridae family within the lentivirus genus. Among the lentiviruses, the two HIV are phylogenetically closer to simian lentiviruses than those infecting other animal species, explaining the antibody crossreactivity observed at first (Chakrabarti et al. 1987). The HIV-2 genome is closest to SIVsm infecting sooty mangabeys (Hirsch et al. 1989), whereas HIV-1 is closest to SIVcpz infecting chimpanzees (Huet et al. 1990)." @default.
- W1787900469 created "2016-06-24" @default.
- W1787900469 creator A5003570981 @default.
- W1787900469 date "2012-01-18" @default.
- W1787900469 modified "2023-10-17" @default.
- W1787900469 title "HIV-2: Testing Specificities" @default.
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- W1787900469 doi "https://doi.org/10.5772/33391" @default.
- W1787900469 hasPublicationYear "2012" @default.
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