FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1787923008> ?p ?o ?g. }

• W1787923008 endingPage "514" @default.
• W1787923008 startingPage "504" @default.
• W1787923008 abstract "Glioblastoma is the most common primary brain tumour in adults. Prognosis is poor: even with the current gold-standard first-line treatment—maximal safe resection and combination of radiotherapy with temozolomide chemotherapy—the median overall survival time is only approximately 15-17 months, because the tumour recurs in virtually all patients, and no commonly accepted standard treatment for recurrent disease exists. Several targeted agents have failed to improve patient outcomes in glioblastoma. Immunotherapy with immune checkpoint inhibitors such as ipilimumab, nivolumab, and pembrolizumab has provided relevant clinical improvements in other advanced tumours for which conventional therapies have had limited success, making immunotherapy an appealing strategy in glioblastoma. This Review summarizes current knowledge on immune checkpoint modulators and evaluates their potential role in glioblastoma on the basis of preclinical studies and emerging clinical data. Furthermore, we discuss challenges that need to be considered in the clinical development of drugs that target immune checkpoint pathways in glioblastoma, such as specific properties of the immune system in the CNS, issues with radiological response assessment, and potential interactions with established and emerging treatment strategies." @default.
• W1787923008 created "2016-06-24" @default.
• W1787923008 creator A5004216670 @default.
• W1787923008 creator A5011340023 @default.
• W1787923008 creator A5037596103 @default.
• W1787923008 creator A5057141936 @default.
• W1787923008 creator A5059965175 @default.
• W1787923008 date "2015-08-11" @default.
• W1787923008 modified "2023-10-14" @default.
• W1787923008 title "Prospects of immune checkpoint modulators in the treatment of glioblastoma" @default.
• W1787923008 cites W1588685142 @default.
• W1787923008 cites W1760562407 @default.
• W1787923008 cites W1823658262 @default.
• W1787923008 cites W1964906491 @default.
• W1787923008 cites W1966999467 @default.
• W1787923008 cites W1970784110 @default.
• W1787923008 cites W1974892500 @default.
• W1787923008 cites W1979651049 @default.
• W1787923008 cites W1979994455 @default.
• W1787923008 cites W1981934675 @default.
• W1787923008 cites W1983955583 @default.
• W1787923008 cites W1985117788 @default.
• W1787923008 cites W1989318291 @default.
• W1787923008 cites W1990675339 @default.
• W1787923008 cites W1993127492 @default.
• W1787923008 cites W1994993231 @default.
• W1787923008 cites W2003417210 @default.
• W1787923008 cites W2004554673 @default.
• W1787923008 cites W2005169943 @default.
• W1787923008 cites W2005518401 @default.
• W1787923008 cites W2008259119 @default.
• W1787923008 cites W2008428974 @default.
• W1787923008 cites W2009720434 @default.
• W1787923008 cites W2013020286 @default.
• W1787923008 cites W2013090484 @default.
• W1787923008 cites W2019607817 @default.
• W1787923008 cites W2024672608 @default.
• W1787923008 cites W2033472418 @default.
• W1787923008 cites W2033672531 @default.
• W1787923008 cites W2035156778 @default.
• W1787923008 cites W2037898720 @default.
• W1787923008 cites W2039664986 @default.
• W1787923008 cites W2044685551 @default.
• W1787923008 cites W2049553585 @default.
• W1787923008 cites W2053393698 @default.
• W1787923008 cites W2056679169 @default.
• W1787923008 cites W2066671159 @default.
• W1787923008 cites W2067315196 @default.
• W1787923008 cites W2075732353 @default.
• W1787923008 cites W2080083059 @default.
• W1787923008 cites W2083991703 @default.
• W1787923008 cites W2091857781 @default.
• W1787923008 cites W2094804545 @default.
• W1787923008 cites W2096287682 @default.
• W1787923008 cites W2097049582 @default.
• W1787923008 cites W2097995306 @default.
• W1787923008 cites W2099854994 @default.
• W1787923008 cites W2100158834 @default.
• W1787923008 cites W2102571808 @default.
• W1787923008 cites W2103220202 @default.
• W1787923008 cites W2104885590 @default.
• W1787923008 cites W2106511606 @default.
• W1787923008 cites W2107055927 @default.
• W1787923008 cites W2107731685 @default.
• W1787923008 cites W2108026478 @default.
• W1787923008 cites W2109465910 @default.
• W1787923008 cites W2109485845 @default.
• W1787923008 cites W2110250914 @default.
• W1787923008 cites W2111963329 @default.
• W1787923008 cites W2113287405 @default.
• W1787923008 cites W2114585110 @default.
• W1787923008 cites W2114701172 @default.
• W1787923008 cites W2116371946 @default.
• W1787923008 cites W2116574496 @default.
• W1787923008 cites W2118982164 @default.
• W1787923008 cites W2119539919 @default.
• W1787923008 cites W2121632584 @default.
• W1787923008 cites W2124199305 @default.
• W1787923008 cites W2124736921 @default.
• W1787923008 cites W2125616358 @default.
• W1787923008 cites W2127446775 @default.
• W1787923008 cites W2131020006 @default.
• W1787923008 cites W2132607958 @default.
• W1787923008 cites W2135707184 @default.
• W1787923008 cites W2137930630 @default.
• W1787923008 cites W2138217326 @default.
• W1787923008 cites W2139591061 @default.
• W1787923008 cites W2143163879 @default.
• W1787923008 cites W2144010265 @default.
• W1787923008 cites W2145592659 @default.
• W1787923008 cites W2148706732 @default.
• W1787923008 cites W2148977460 @default.
• W1787923008 cites W2149387197 @default.
• W1787923008 cites W2151246207 @default.
• W1787923008 cites W2152980179 @default.
• W1787923008 cites W2153193885 @default.
• W1787923008 cites W2153778867 @default.
• W1787923008 cites W2156330848 @default.

• next