Matches in SemOpenAlex for { <https://semopenalex.org/work/W1788339898> ?p ?o ?g. }
- W1788339898 endingPage "210" @default.
- W1788339898 startingPage "204" @default.
- W1788339898 abstract "Heart failure is a major and growing public health problem with a high mortality rate. Although recent studies have demonstrated that a variety of metabolic and/or neurohumoral factors are involved in the progression of this syndrome, the precise mechanisms responsible for this complex condition are poorly understood.To examine 123I-beta-methyl-iodophenylpentadecanoic acid (BMIPP) kinetics in the early phase soon after tracer injection in patients with congestive heart failure (CHF), we performed dynamic single-photon emission computed tomography (SPECT).Twenty-six patients with CHF and eight control subjects were examined. The consecutive 15 images of 2-min dynamic SPECT were acquired for 30 min after injection. In the early phase after injection (0-4 min), a significant amount of radioactivity existed in the blood pool. After 6 min, the myocardial 123I-BMIPP image was clear and thus the washout rate of 123I-BMIPP from 6 to 30 min was calculated.The washout rate of 123I-BMIPP from the myocardium was faster in patients with CHF than in the controls (8 +/- 4 vs. -5 +/- 3%, p < 0.01). The washout rate of 123I-BMIPP demonstrated positive correlation with left ventricular (LV) end-diastolic volume index (R = 0.54, p < 0.02) and inverse correlation with LV ejection fraction (R = 0.53, p <0.02). Patients were given the angiotensin II type-1 receptor antagonist candesartan for 6 months, and dynamic SPECT was repeated. The enhanced washout rate of 123I-BMIPP in CHF was reduced after treatment with candesartan (p < 0.05).These data suggest that (1) enhanced washout of 123I-BMIPP was observed soon after injection in patients with CHF, (2) the activation of angiotensin II signaling pathway is involved as an intracellular mechanism for enhanced 123I-BMIPP washout in heart failure, and (3) improvement in fatty acid metabolism may represent a new mechanism for beneficial effects of angiotensin II receptor blockade on cardiac function and survival in patients with heart failure. 123I-BMIPP washout in the early phase obtained from dynamic SPECT may be a new marker for evaluating the severity of heart failure and the effects of medical treatment." @default.
- W1788339898 created "2016-06-24" @default.
- W1788339898 creator A5001675814 @default.
- W1788339898 creator A5003545994 @default.
- W1788339898 creator A5004466344 @default.
- W1788339898 creator A5012638915 @default.
- W1788339898 creator A5016237352 @default.
- W1788339898 creator A5018539336 @default.
- W1788339898 creator A5021980499 @default.
- W1788339898 creator A5024207785 @default.
- W1788339898 creator A5059022644 @default.
- W1788339898 creator A5070213646 @default.
- W1788339898 creator A5071632812 @default.
- W1788339898 creator A5076092034 @default.
- W1788339898 creator A5077534241 @default.
- W1788339898 creator A5078250646 @default.
- W1788339898 creator A5084813062 @default.
- W1788339898 creator A5085388421 @default.
- W1788339898 date "2004-04-01" @default.
- W1788339898 modified "2023-10-14" @default.
- W1788339898 title "Dynamic123I-BMIPP single-photon emission computed tomography in patients with congestive heart failure: Effect of angiotensin ii type-1 receptor blockade" @default.
- W1788339898 cites W1519435985 @default.
- W1788339898 cites W1761438761 @default.
- W1788339898 cites W1826147657 @default.
- W1788339898 cites W1986489016 @default.
- W1788339898 cites W1991184697 @default.
- W1788339898 cites W1998328589 @default.
- W1788339898 cites W1999270831 @default.
- W1788339898 cites W1999766083 @default.
- W1788339898 cites W2003497946 @default.
- W1788339898 cites W2006165957 @default.
- W1788339898 cites W2020464685 @default.
- W1788339898 cites W2033767220 @default.
- W1788339898 cites W2041976667 @default.
- W1788339898 cites W2047516245 @default.
- W1788339898 cites W2048454916 @default.
- W1788339898 cites W2056893352 @default.
- W1788339898 cites W2059744229 @default.
- W1788339898 cites W2060300790 @default.
- W1788339898 cites W2088476894 @default.
- W1788339898 cites W2096780232 @default.
- W1788339898 cites W2118955611 @default.
- W1788339898 cites W2128382361 @default.
- W1788339898 cites W2151188537 @default.
- W1788339898 cites W2154584898 @default.
- W1788339898 cites W2168161582 @default.
- W1788339898 cites W2183885017 @default.
- W1788339898 cites W2271778402 @default.
- W1788339898 cites W2475261460 @default.
- W1788339898 doi "https://doi.org/10.1002/clc.4960270406" @default.
- W1788339898 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6654307" @default.
- W1788339898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15119694" @default.
- W1788339898 hasPublicationYear "2004" @default.
- W1788339898 type Work @default.
- W1788339898 sameAs 1788339898 @default.
- W1788339898 citedByCount "7" @default.
- W1788339898 countsByYear W17883398982016 @default.
- W1788339898 countsByYear W17883398982018 @default.
- W1788339898 countsByYear W17883398982019 @default.
- W1788339898 crossrefType "journal-article" @default.
- W1788339898 hasAuthorship W1788339898A5001675814 @default.
- W1788339898 hasAuthorship W1788339898A5003545994 @default.
- W1788339898 hasAuthorship W1788339898A5004466344 @default.
- W1788339898 hasAuthorship W1788339898A5012638915 @default.
- W1788339898 hasAuthorship W1788339898A5016237352 @default.
- W1788339898 hasAuthorship W1788339898A5018539336 @default.
- W1788339898 hasAuthorship W1788339898A5021980499 @default.
- W1788339898 hasAuthorship W1788339898A5024207785 @default.
- W1788339898 hasAuthorship W1788339898A5059022644 @default.
- W1788339898 hasAuthorship W1788339898A5070213646 @default.
- W1788339898 hasAuthorship W1788339898A5071632812 @default.
- W1788339898 hasAuthorship W1788339898A5076092034 @default.
- W1788339898 hasAuthorship W1788339898A5077534241 @default.
- W1788339898 hasAuthorship W1788339898A5078250646 @default.
- W1788339898 hasAuthorship W1788339898A5084813062 @default.
- W1788339898 hasAuthorship W1788339898A5085388421 @default.
- W1788339898 hasBestOaLocation W17883398982 @default.
- W1788339898 hasConcept C104849204 @default.
- W1788339898 hasConcept C126322002 @default.
- W1788339898 hasConcept C164705383 @default.
- W1788339898 hasConcept C170493617 @default.
- W1788339898 hasConcept C2778198053 @default.
- W1788339898 hasConcept C2780036600 @default.
- W1788339898 hasConcept C2780441642 @default.
- W1788339898 hasConcept C2908929049 @default.
- W1788339898 hasConcept C71839028 @default.
- W1788339898 hasConcept C71924100 @default.
- W1788339898 hasConcept C78085059 @default.
- W1788339898 hasConceptScore W1788339898C104849204 @default.
- W1788339898 hasConceptScore W1788339898C126322002 @default.
- W1788339898 hasConceptScore W1788339898C164705383 @default.
- W1788339898 hasConceptScore W1788339898C170493617 @default.
- W1788339898 hasConceptScore W1788339898C2778198053 @default.
- W1788339898 hasConceptScore W1788339898C2780036600 @default.
- W1788339898 hasConceptScore W1788339898C2780441642 @default.
- W1788339898 hasConceptScore W1788339898C2908929049 @default.
- W1788339898 hasConceptScore W1788339898C71839028 @default.
- W1788339898 hasConceptScore W1788339898C71924100 @default.