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- W1788593926 abstract "To find new H + /K + ‐ATPase inhibitors for the treatment of peptic ulcer disease, a series of novel N ‐aryl isothiourea derivatives were synthesized and their structures were identified by 1 H NMR and GC‐MS. The effects of these compounds on inhibiting gastric acid secretion were evaluated by the guinea pig stomach mucous membrane study with pantoprazole magnesium as a positive control. The results showed that, of the 37 N ‐aryl isothiourea compounds synthesized, 20 compounds have comparable or stronger gastric acid inhibitory activities than that of pantoprazole magnesium. The quantitative structure–activity relationships (QSARs) of the N ‐aryl isothiourea compounds were also studied by comparative molecular field analysis (CoMFA) computation, and the model structure that was supposed to give more powerful bioactivities was finally predicted." @default.
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- W1788593926 date "2013-10-30" @default.
- W1788593926 modified "2023-10-11" @default.
- W1788593926 title "Design and Synthesis of<i>N</i>-Aryl Isothioureas as a Novel Class of Gastric H<sup>+</sup>/K<sup>+</sup>-ATPase Inhibitors" @default.
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- W1788593926 doi "https://doi.org/10.1002/ardp.201300276" @default.
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