FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1788653759> ?p ?o ?g. }

• W1788653759 endingPage "9" @default.
• W1788653759 startingPage "1653" @default.
• W1788653759 abstract "Malignant tumors metabolize glucose to lactate even in the presence of oxygen (aerobic glycolysis). The metabolic switch from oxidative glycolysis to non-oxidative fermentation of glucose and proteins performed by the tumor cells seems to be associated with TKTL1 and pAkt overexpression. Therefore the aim of the present study was to investigate the expression of TKTL1 and pAkt in human specimens of endometrial cancer as compared to benign endometrium. Additionally, expression of the glucose transporter GLUT1 was also investigated as aerobic glycolysis is associated with an increased need for glucose.Levels of TKTL1, pAkt, and GLUT1 expression were immunhistochemically evaluated on paraffin embedded biopsy material from 10 benign and 41 malignant endometrial tissue samples. TKTL1 mRNA levels in the endometrial cancer cell lines Ishikawa and HEC-1A were evaluated by RT-PCR.Expression of TKTL1, GLUT1 and pAKT was significantly increased in endometrial carcinomas as compared to benign endometrial tissue. There was a significantly weaker TKTL1 expression in highly differentiated G1 tumors. In the human endometrial cancer cell lines Ishikawa and HEC-1A, TKTL1 mRNA was clearly detectable.The levels of TKTL1, GLUT1 and pAKT expression point to the glycolytic phenotype of malignant endometrial tissue. Given the pronounced TKTL1 expression across all different subtypes of endometrial cancer, this protein could serve as a target for future cancer treatments." @default.
• W1788653759 created "2016-06-24" @default.
• W1788653759 creator A5017254542 @default.
• W1788653759 creator A5019106804 @default.
• W1788653759 creator A5033540298 @default.
• W1788653759 creator A5037403363 @default.
• W1788653759 creator A5054575121 @default.
• W1788653759 creator A5061019605 @default.
• W1788653759 creator A5063671588 @default.
• W1788653759 creator A5081473975 @default.
• W1788653759 creator A5082215355 @default.
• W1788653759 date "2010-05-01" @default.
• W1788653759 modified "2023-09-26" @default.
• W1788653759 title "Expression of transketolase-like 1 protein (TKTL1) in human endometrial cancer." @default.
• W1788653759 cites W1906667240 @default.
• W1788653759 cites W1940014006 @default.
• W1788653759 cites W1963901057 @default.
• W1788653759 cites W1966447268 @default.
• W1788653759 cites W1971859682 @default.
• W1788653759 cites W1974541564 @default.
• W1788653759 cites W1975227141 @default.
• W1788653759 cites W1986985303 @default.
• W1788653759 cites W1987784827 @default.
• W1788653759 cites W1993981670 @default.
• W1788653759 cites W1995679812 @default.
• W1788653759 cites W2002752049 @default.
• W1788653759 cites W2006294797 @default.
• W1788653759 cites W2007169088 @default.
• W1788653759 cites W2019789647 @default.
• W1788653759 cites W2044958267 @default.
• W1788653759 cites W2045962235 @default.
• W1788653759 cites W2087729559 @default.
• W1788653759 cites W2114358693 @default.
• W1788653759 cites W2121727754 @default.
• W1788653759 cites W2126452795 @default.
• W1788653759 cites W2130503287 @default.
• W1788653759 cites W2136927815 @default.
• W1788653759 cites W2145043162 @default.
• W1788653759 cites W2150419930 @default.
• W1788653759 cites W2151547720 @default.
• W1788653759 cites W2152210952 @default.
• W1788653759 cites W2154794447 @default.
• W1788653759 cites W2170904194 @default.
• W1788653759 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20592357" @default.
• W1788653759 hasPublicationYear "2010" @default.
• W1788653759 type Work @default.
• W1788653759 sameAs 1788653759 @default.
• W1788653759 citedByCount "16" @default.
• W1788653759 countsByYear W17886537592013 @default.
• W1788653759 countsByYear W17886537592015 @default.
• W1788653759 countsByYear W17886537592016 @default.
• W1788653759 countsByYear W17886537592019 @default.
• W1788653759 countsByYear W17886537592022 @default.
• W1788653759 countsByYear W17886537592023 @default.
• W1788653759 crossrefType "journal-article" @default.
• W1788653759 hasAuthorship W1788653759A5017254542 @default.
• W1788653759 hasAuthorship W1788653759A5019106804 @default.
• W1788653759 hasAuthorship W1788653759A5033540298 @default.
• W1788653759 hasAuthorship W1788653759A5037403363 @default.
• W1788653759 hasAuthorship W1788653759A5054575121 @default.
• W1788653759 hasAuthorship W1788653759A5061019605 @default.
• W1788653759 hasAuthorship W1788653759A5063671588 @default.
• W1788653759 hasAuthorship W1788653759A5081473975 @default.
• W1788653759 hasAuthorship W1788653759A5082215355 @default.
• W1788653759 hasConcept C121608353 @default.
• W1788653759 hasConcept C126322002 @default.
• W1788653759 hasConcept C134018914 @default.
• W1788653759 hasConcept C161573976 @default.
• W1788653759 hasConcept C20251656 @default.
• W1788653759 hasConcept C204232928 @default.
• W1788653759 hasConcept C2777088508 @default.
• W1788653759 hasConcept C2777952866 @default.
• W1788653759 hasConcept C2778515176 @default.
• W1788653759 hasConcept C2779306644 @default.
• W1788653759 hasConcept C502942594 @default.
• W1788653759 hasConcept C55885012 @default.
• W1788653759 hasConcept C62231903 @default.
• W1788653759 hasConcept C71924100 @default.
• W1788653759 hasConcept C86803240 @default.
• W1788653759 hasConcept C96232424 @default.
• W1788653759 hasConceptScore W1788653759C121608353 @default.
• W1788653759 hasConceptScore W1788653759C126322002 @default.
• W1788653759 hasConceptScore W1788653759C134018914 @default.
• W1788653759 hasConceptScore W1788653759C161573976 @default.
• W1788653759 hasConceptScore W1788653759C20251656 @default.
• W1788653759 hasConceptScore W1788653759C204232928 @default.
• W1788653759 hasConceptScore W1788653759C2777088508 @default.
• W1788653759 hasConceptScore W1788653759C2777952866 @default.
• W1788653759 hasConceptScore W1788653759C2778515176 @default.
• W1788653759 hasConceptScore W1788653759C2779306644 @default.
• W1788653759 hasConceptScore W1788653759C502942594 @default.
• W1788653759 hasConceptScore W1788653759C55885012 @default.
• W1788653759 hasConceptScore W1788653759C62231903 @default.
• W1788653759 hasConceptScore W1788653759C71924100 @default.
• W1788653759 hasConceptScore W1788653759C86803240 @default.
• W1788653759 hasConceptScore W1788653759C96232424 @default.
• W1788653759 hasIssue "5" @default.
• W1788653759 hasLocation W17886537591 @default.

• next