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• W1788768627 endingPage "3417" @default.
• W1788768627 startingPage "3410" @default.
• W1788768627 abstract "Activated v-myc (pSV v-myc) and v-Ha-ras (GT10) oncogenes were introduced into normal human lymphocytes, NIH 3T3 fibroblasts, B-lymphoblastoid cells, and human epithelial cells, using a reconstituted Sendai virus envelope-mediated gene transfer technique. Efficient transfer of the plasmid in each cell type was demonstrable within 1.5 h of transfection by Southern blotting of extrachromosomal DNA extracts, which unexpectedly revealed that v-myc plasmid DNA was unstable in normal lymphocytes but not in the other cell types. The v-myc plasmid was stabilized when cotransfected into lymphocytes together with v-Ha-ras. The transfected v-Ha-ras plasmid was stable in all the cell types tested. v-myc plasmid expression was clearly detectable by 5 h in all cell types except human lymphocytes. Lymphocytes expressed v-myc when transfected together with v-Ha-ras. Transfected ras oncogene was efficiently expressed in all the cell types tested. Expression of the transfected genes increased at 24 and 48 h after transfection. Even though plasmid stability and expression were achieved in myc-ras-cotransfected lymphocytes, no effects on cellular DNA synthesis or immortalization were observed, in contrast to efficient transformation of NIH 3T3 fibroblasts by the same procedure. Our data suggest that efficient expression of transfected myc and ras oncogenes in normal quiescent human lymphocytes is not sufficient for the induction of cell growth and immortalization." @default.
• W1788768627 created "2016-06-24" @default.
• W1788768627 creator A5046772826 @default.
• W1788768627 creator A5063343955 @default.
• W1788768627 date "1986-10-01" @default.
• W1788768627 modified "2023-10-18" @default.
• W1788768627 title "Activated v-myc and v-ras oncogenes do not transform normal human lymphocytes." @default.
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• W1788768627 doi "https://doi.org/10.1128/mcb.6.10.3410" @default.
• W1788768627 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/367088" @default.
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• W1788768627 hasPublicationYear "1986" @default.
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