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- W1788809310 abstract "textabstractThe liver is the largest organ in the body with essential metabolic activities. In the liverlarge amounts of oxygenated blood carried by the hepatic artery are used to mobilizeenergy from dietary components. Toxic compounds, derived from food are transportedfrom the bowel via the portal vein and detoxifi ed in the liver. In order to avoid unwarrantedresponses to harmless dietary proteins and components of the commensal intestinalfl ora, tight control of the local immune response in the liver is mandatory. However asa consequence the liver is a target for chronic viral and parasitic infections and metastasisof malignant diseases develop relatively easily in the liver. To meet these specifi c requirements,the repertoire of immune cells present in the liver differs dramatically fromthose in other non-lymphoid tissues of the body, and is considered to play a specializedrole in hepatic immune responses.The liver hosts various unique resident cell types with immune potential, such as a lymphoidpopulation selectively enriched for CD8+ T cells, NK cells and NKT cells, andcells with accessory immunologic functions such as dendritic cells (DC), Kupffer cells,sinusoidal endothelial cells and biliary epithelial cells. It is hypothesized that DC, themost potent antigen presenting cells, are the key players in maintaining the fi ne balancebetween immune responsiveness and unresponsiveness in the liver. Under normalcircumstances, most peripheral tissues, such as the liver, contain immature DC, whosefunction is uptake and processing of antigen. Under steady state conditions there is acontinuous migration of DC towards the draining lymph nodes (LN) and this process isaccelerated upon antigenic stimulation. During this migration DC mature and acquire astrong T cell stimulatory capacity." @default.
- W1788809310 created "2016-06-24" @default.
- W1788809310 creator A5024099214 @default.
- W1788809310 date "2008-03-05" @default.
- W1788809310 modified "2023-09-22" @default.
- W1788809310 title "Immunomodulation after Liver Transplantation: a role for dentritic cells" @default.
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