Matches in SemOpenAlex for { <https://semopenalex.org/work/W1789274326> ?p ?o ?g. }
- W1789274326 endingPage "494" @default.
- W1789274326 startingPage "482" @default.
- W1789274326 abstract "The low molecular weight protein tyrosine phosphatase (LMPTP), encoded by the ACP1 gene, is a ubiquitously expressed phosphatase whose in vivo function in the heart and in cardiac diseases remains unknown. To investigate the in vivo role of LMPTP in cardiac function, we generated mice with genetic inactivation of the Acp1 locus and studied their response to long-term pressure overload. Acp1(-/-) mice develop normally and ageing mice do not show pathology in major tissues under basal conditions. However, Acp1(-/-) mice are strikingly resistant to pressure overload hypertrophy and heart failure. Lmptp expression is high in the embryonic mouse heart, decreased in the postnatal stage, and increased in the adult mouse failing heart. We also show that LMPTP expression increases in end-stage heart failure in humans. Consistent with their protected phenotype, Acp1(-/-) mice subjected to pressure overload hypertrophy have attenuated fibrosis and decreased expression of fibrotic genes. Transcriptional profiling and analysis of molecular signalling show that the resistance of Acp1(-/-) mice to pathological cardiac stress correlates with marginal re-expression of fetal cardiac genes, increased insulin receptor beta phosphorylation, as well as PKA and ephrin receptor expression, and inactivation of the CaMKIIδ pathway. Our data show that ablation of Lmptp inhibits pathological cardiac remodelling and suggest that inhibition of LMPTP may be of therapeutic relevance for the treatment of human heart failure." @default.
- W1789274326 created "2016-06-24" @default.
- W1789274326 creator A5003156274 @default.
- W1789274326 creator A5003393607 @default.
- W1789274326 creator A5003866488 @default.
- W1789274326 creator A5008588721 @default.
- W1789274326 creator A5012359974 @default.
- W1789274326 creator A5016899134 @default.
- W1789274326 creator A5026853575 @default.
- W1789274326 creator A5027360557 @default.
- W1789274326 creator A5032978625 @default.
- W1789274326 creator A5034199163 @default.
- W1789274326 creator A5041015261 @default.
- W1789274326 creator A5044788921 @default.
- W1789274326 creator A5050077508 @default.
- W1789274326 creator A5051306751 @default.
- W1789274326 creator A5053774360 @default.
- W1789274326 creator A5062146592 @default.
- W1789274326 creator A5074558279 @default.
- W1789274326 creator A5079182899 @default.
- W1789274326 creator A5088106727 @default.
- W1789274326 creator A5088544965 @default.
- W1789274326 creator A5091014766 @default.
- W1789274326 date "2015-09-01" @default.
- W1789274326 modified "2023-10-10" @default.
- W1789274326 title "Deletion of low molecular weight protein tyrosine phosphatase ( <i>Acp1</i> ) protects against stress‐induced cardiomyopathy" @default.
- W1789274326 cites W1502059201 @default.
- W1789274326 cites W1516095885 @default.
- W1789274326 cites W1969040215 @default.
- W1789274326 cites W1973614663 @default.
- W1789274326 cites W1975327945 @default.
- W1789274326 cites W1978619474 @default.
- W1789274326 cites W1979347978 @default.
- W1789274326 cites W1979973024 @default.
- W1789274326 cites W1981355782 @default.
- W1789274326 cites W1991670552 @default.
- W1789274326 cites W1994146439 @default.
- W1789274326 cites W2001261561 @default.
- W1789274326 cites W2013102754 @default.
- W1789274326 cites W2013668219 @default.
- W1789274326 cites W2015247168 @default.
- W1789274326 cites W2018961120 @default.
- W1789274326 cites W2021458745 @default.
- W1789274326 cites W2036272929 @default.
- W1789274326 cites W2038437697 @default.
- W1789274326 cites W2040846930 @default.
- W1789274326 cites W2043617798 @default.
- W1789274326 cites W2058205536 @default.
- W1789274326 cites W2062055994 @default.
- W1789274326 cites W2072962748 @default.
- W1789274326 cites W2078506965 @default.
- W1789274326 cites W2082110878 @default.
- W1789274326 cites W2090337553 @default.
- W1789274326 cites W2100347223 @default.
- W1789274326 cites W2100637689 @default.
- W1789274326 cites W2105830710 @default.
- W1789274326 cites W2107277218 @default.
- W1789274326 cites W2108819945 @default.
- W1789274326 cites W2112230125 @default.
- W1789274326 cites W2112930305 @default.
- W1789274326 cites W2113934901 @default.
- W1789274326 cites W2119389187 @default.
- W1789274326 cites W2120127702 @default.
- W1789274326 cites W2122683221 @default.
- W1789274326 cites W2132390559 @default.
- W1789274326 cites W2133465414 @default.
- W1789274326 cites W2135975711 @default.
- W1789274326 cites W2140067862 @default.
- W1789274326 cites W2140732346 @default.
- W1789274326 cites W2150765336 @default.
- W1789274326 cites W2152190194 @default.
- W1789274326 cites W2152477185 @default.
- W1789274326 cites W2158217645 @default.
- W1789274326 cites W2160697532 @default.
- W1789274326 cites W2162489885 @default.
- W1789274326 cites W2165965394 @default.
- W1789274326 cites W2192080449 @default.
- W1789274326 cites W45534775 @default.
- W1789274326 doi "https://doi.org/10.1002/path.4594" @default.
- W1789274326 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5049627" @default.
- W1789274326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26213100" @default.
- W1789274326 hasPublicationYear "2015" @default.
- W1789274326 type Work @default.
- W1789274326 sameAs 1789274326 @default.
- W1789274326 citedByCount "11" @default.
- W1789274326 countsByYear W17892743262017 @default.
- W1789274326 countsByYear W17892743262018 @default.
- W1789274326 countsByYear W17892743262020 @default.
- W1789274326 countsByYear W17892743262021 @default.
- W1789274326 countsByYear W17892743262022 @default.
- W1789274326 crossrefType "journal-article" @default.
- W1789274326 hasAuthorship W1789274326A5003156274 @default.
- W1789274326 hasAuthorship W1789274326A5003393607 @default.
- W1789274326 hasAuthorship W1789274326A5003866488 @default.
- W1789274326 hasAuthorship W1789274326A5008588721 @default.
- W1789274326 hasAuthorship W1789274326A5012359974 @default.
- W1789274326 hasAuthorship W1789274326A5016899134 @default.
- W1789274326 hasAuthorship W1789274326A5026853575 @default.