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- W1789432895 abstract "Androgen ablation is the most commonly used therapy for prostate cancer. However, the effects of androgen ablation on immune system, especially B cell distribution are not well understood. We have used transgenic adenocarcinoma mouse prostate (TRAMP) mice to characterize the B cell distribution in periphery blood and spleen upon androgen ablation. We found a decrease of the B cell population in wild type TRAMP mice compared to normal wild type mice. Furthermore, the B cells increased when in castrated TRAMP mice compared to the wild type TRAMP mice. Interestingly, we found an increase in immature B cells in the spleen of castrated TRAMP mice, which might be due to the resistance to apoptosis during B cell maturation. Our data suggest that androgen ablation might play an important role in the regulation of B cell tolerance." @default.
- W1789432895 created "2016-06-24" @default.
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- W1789432895 date "2014-07-01" @default.
- W1789432895 modified "2023-09-27" @default.
- W1789432895 title "Androgen Ablation Mitigates Defect of B Cells to a Prostate Cancer and Increase Survival Rate of Tramp Mice" @default.
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- W1789432895 doi "https://doi.org/10.12816/0009468" @default.
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