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• W1789713350 endingPage "12" @default.
• W1789713350 startingPage "1" @default.
• W1789713350 abstract "Coronary artery spasm plays an important role in the pathogenesis of a wide variety of ischemic heart diseases, especially in the Japanese population. Because coronary artery spasm can be induced by a variety of stimuli with different mechanisms of action, the occurrence of the spasm appears to be due to the local hyperreactivity of the coronary artery rather than to an enhanced stimulation with a single mechanism of action. Several lines of evidence indicate that coronary artery spasm is caused primarily by smooth muscle hypercontraction whereas the contribution of endothelial dysfunction may be minimal. In order to elucidate the cellular and molecular mechanisms of the spasm, porcine models of the spasm were developed. In the first model with balloon injury and high-cholesterol feeding, a close topological correlation between the early atherosclerotic lesions and the spastic sites was noted, whereas in the second model with an inflammatory cytokine the potential importance of coronary inflammatory changes, especially at the adventitia, was noted. Subsequent studies in vivo and in vitro demonstrated that protein kinase C (PKC) and Rho-kinase are substantially involved in the intracellular mechanism of the spasm, resulting in increases in the mono- and diphosphorylations of myosin light chain (MLC). Furthermore, molecular biological analyses demonstrated that Rho-kinase is upregulated at the spastic site (at all levels, including mRNA, protein, and activity), resulting in the inhibiton of MLC phosphatase through the phosphorylation of its myosin binding subunit and thereby causing the increase in MLC phosphorylations. Preliminary results also suggest that the long-term inhibition of Rho-kinase is effective in inhibiting the development of arteriosclerotic vascular lesions in several porcine models. Thus, Rho-kinase could be regarded as a novel therapeutic target for coronary arteriosclerosis in general and coronary artery spasm in particular." @default.
• W1789713350 created "2016-06-24" @default.
• W1789713350 creator A5012657143 @default.
• W1789713350 date "2000-01-01" @default.
• W1789713350 modified "2023-09-27" @default.
• W1789713350 title "Cellular and Molecular Mechanisms of Coronary Artery Spasm" @default.
• W1789713350 cites W1514066364 @default.
• W1789713350 cites W1518499796 @default.
• W1789713350 cites W1568617917 @default.
• W1789713350 cites W1597787921 @default.
• W1789713350 cites W1599285393 @default.
• W1789713350 cites W1848552725 @default.
• W1789713350 cites W1857294168 @default.
• W1789713350 cites W1963492621 @default.
• W1789713350 cites W1965409012 @default.
• W1789713350 cites W1967058825 @default.
• W1789713350 cites W1967578418 @default.
• W1789713350 cites W1969964507 @default.
• W1789713350 cites W1971122576 @default.
• W1789713350 cites W1974146867 @default.
• W1789713350 cites W1977090605 @default.
• W1789713350 cites W1978039310 @default.
• W1789713350 cites W1979890127 @default.
• W1789713350 cites W1980166477 @default.
• W1789713350 cites W1982457725 @default.
• W1789713350 cites W1984272587 @default.
• W1789713350 cites W1994147612 @default.
• W1789713350 cites W1996200557 @default.
• W1789713350 cites W1997087774 @default.
• W1789713350 cites W1997722136 @default.
• W1789713350 cites W1998549792 @default.
• W1789713350 cites W2000842099 @default.
• W1789713350 cites W2004997642 @default.
• W1789713350 cites W2007176335 @default.
• W1789713350 cites W2012768742 @default.
• W1789713350 cites W2013545198 @default.
• W1789713350 cites W2013836257 @default.
• W1789713350 cites W2014234136 @default.
• W1789713350 cites W2014476914 @default.
• W1789713350 cites W2020993672 @default.
• W1789713350 cites W2021174692 @default.
• W1789713350 cites W2021522627 @default.
• W1789713350 cites W2025340288 @default.
• W1789713350 cites W2028329330 @default.
• W1789713350 cites W2030480783 @default.
• W1789713350 cites W2032295238 @default.
• W1789713350 cites W2034683404 @default.
• W1789713350 cites W2041776989 @default.
• W1789713350 cites W2052219197 @default.
• W1789713350 cites W2053705719 @default.
• W1789713350 cites W2053845536 @default.
• W1789713350 cites W2054305298 @default.
• W1789713350 cites W2059076379 @default.
• W1789713350 cites W2061963362 @default.
• W1789713350 cites W2062129029 @default.
• W1789713350 cites W2064595265 @default.
• W1789713350 cites W2065262403 @default.
• W1789713350 cites W2066668911 @default.
• W1789713350 cites W2067000184 @default.
• W1789713350 cites W2067735833 @default.
• W1789713350 cites W2067926908 @default.
• W1789713350 cites W2068590281 @default.
• W1789713350 cites W2068878178 @default.
• W1789713350 cites W2077731863 @default.
• W1789713350 cites W2077948419 @default.
• W1789713350 cites W2078992684 @default.
• W1789713350 cites W2079049802 @default.
• W1789713350 cites W2082691733 @default.
• W1789713350 cites W2083647583 @default.
• W1789713350 cites W2084769286 @default.
• W1789713350 cites W2089742414 @default.
• W1789713350 cites W2092277717 @default.
• W1789713350 cites W2092484320 @default.
• W1789713350 cites W2093455882 @default.
• W1789713350 cites W2095085620 @default.
• W1789713350 cites W2111953462 @default.
• W1789713350 cites W2114278094 @default.
• W1789713350 cites W2115427263 @default.
• W1789713350 cites W2118650093 @default.
• W1789713350 cites W2123005135 @default.
• W1789713350 cites W2133570574 @default.
• W1789713350 cites W2137570167 @default.
• W1789713350 cites W2155232923 @default.
• W1789713350 cites W2162049443 @default.
• W1789713350 cites W2164613405 @default.
• W1789713350 cites W2167837970 @default.
• W1789713350 cites W2168223223 @default.
• W1789713350 cites W2175568527 @default.
• W1789713350 cites W2193864892 @default.
• W1789713350 cites W2375169070 @default.
• W1789713350 cites W2614758074 @default.
• W1789713350 cites W3194355700 @default.
• W1789713350 cites W4211053163 @default.
• W1789713350 cites W4231679076 @default.
• W1789713350 cites W4232634739 @default.
• W1789713350 cites W4361865076 @default.
• W1789713350 cites W1512144932 @default.
• W1789713350 doi "https://doi.org/10.1253/jcj.64.1" @default.

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