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- W1789804701 abstract "<b><i>Background:</i></b> The regional citrate anticoagulation (RCA) induces changes in total (Ca<sup>tot</sup>) and ionized (Ca<sup>2+</sup>) calcium. As of now, we do not have much information about parallel changes of total (Mg<sup>tot</sup>) and ionized (Mg<sup>2+</sup>) magnesium. <b><i>Methods:</i></b> The authors compared changes of Mg<sup>2+</sup> and Mg<sup>tot</sup> with changes of Ca<sup>2+</sup> and Ca<sup>tot</sup> in 32 critically ill patients on 4% trisodium citrate (4% TSC) with calcium-free fluids. <b><i>Results:</i></b> The median continuous venovenous hemodiafiltration balance of Mg<sup>tot</sup> was -0.91 (-1.18 to -0.53) mmol/h compared to the median balance of Ca<sup>tot</sup> 0.86 (0.08-1.55) mmol/h. Postfilter Mg<sup>2+</sup> decreased by 68.3% (70.8-65.6) in parallel (r = 0.41, p = 0.03) to decrease of postfilter Ca<sup>2+</sup> (by 70.2% (73.0-66.1)) and was significantly related to the postfilter Ca<sup>2+</sup> (r = 0.50, p < 0.001). The decrease of prefilter to postfilter Ca<sup>2+</sup> correlated to a dosage of 4% TSC per blood flow (r = 0.37, p = 0.04). <b><i>Conclusions:</i></b> The loss of Mg<sup>tot</sup> during RCA is not covered by magnesium concentration in ordinary dialysis/substitution fluid and may lead to the depletion of total body magnesium. The postfilter Mg<sup>2+</sup> is significantly related to the postfilter Ca<sup>2+</sup>. Video Journal Club “Cappuccino with Claudio Ronco” at http://www.karger.com/?doi = 440972." @default.
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- W1789804701 date "2015-10-20" @default.
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- W1789804701 title "Ionized Magnesium and Regional Citrate Anticoagulation for Continuous Renal Replacement Therapy" @default.
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- W1789804701 doi "https://doi.org/10.1159/000440972" @default.
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