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- W1790185087 endingPage "1075" @default.
- W1790185087 startingPage "1061" @default.
- W1790185087 abstract "Metreleptin was recently approved by the Food and Drug Administration for the treatment of generalized lipodystrophy, a condition characterized by leptin deficiency. Its efficacy as hormone replacement therapy suggests broader applications in diseases also characterized by leptin abnormalities, such as familial partial lipodystrophy (FPLD), non-alcoholic fatty liver disease (NAFLD), and common obesity. Metreleptin, in conjunction with other pharmacologic interventions, has the potential to address one of the most widespread epidemics of our time, obesity.This review covers the physiology of leptin, the pharmacologic properties of recombinant methionyl human leptin (R-metHu-Leptin, metreleptin), evidence for metreleptin's efficacy in the treatment of generalized lipodystrophy from both completed and ongoing clinical trials, safety concerns, and future directions in metreleptin research.Metreleptin's approval for generalized lipodystrophy is the first step in defining and expanding its role to other metabolic diseases. Clinical trials are underway to delineate its efficacy in FPLD, human immunodeficiency virus/highly active anti-retroviral therapy-associated acquired lipodystrophy (HAL), and NAFLD. Additionally, there is growing data that support a therapeutic role in obesity. One of the barriers to development, however, is metreleptin's safety and immunogenicity. Further advances in biologic compatibility are required before metreleptin can be approved for additional indications." @default.
- W1790185087 created "2016-06-24" @default.
- W1790185087 creator A5051043505 @default.
- W1790185087 creator A5067746796 @default.
- W1790185087 creator A5072258113 @default.
- W1790185087 date "2015-06-10" @default.
- W1790185087 modified "2023-10-10" @default.
- W1790185087 title "Metreleptin and generalized lipodystrophy and evolving therapeutic perspectives" @default.
- W1790185087 cites W1492605893 @default.
- W1790185087 cites W1493322662 @default.
- W1790185087 cites W1646872714 @default.
- W1790185087 cites W1884023537 @default.
- W1790185087 cites W1943524962 @default.
- W1790185087 cites W1964183737 @default.
- W1790185087 cites W1964786588 @default.
- W1790185087 cites W1976081253 @default.
- W1790185087 cites W1979354059 @default.
- W1790185087 cites W1981452149 @default.
- W1790185087 cites W1984053203 @default.
- W1790185087 cites W1990407738 @default.
- W1790185087 cites W1993088616 @default.
- W1790185087 cites W1996713062 @default.
- W1790185087 cites W1996800212 @default.
- W1790185087 cites W1997970568 @default.
- W1790185087 cites W2001929198 @default.
- W1790185087 cites W2001980298 @default.
- W1790185087 cites W2007482590 @default.
- W1790185087 cites W2009330135 @default.
- W1790185087 cites W2010072332 @default.
- W1790185087 cites W2014093920 @default.
- W1790185087 cites W2018675431 @default.
- W1790185087 cites W2019967420 @default.
- W1790185087 cites W2020248048 @default.
- W1790185087 cites W2020803051 @default.
- W1790185087 cites W2024050954 @default.
- W1790185087 cites W2024129510 @default.
- W1790185087 cites W2026866948 @default.
- W1790185087 cites W2027112907 @default.
- W1790185087 cites W2027664697 @default.
- W1790185087 cites W2031355616 @default.
- W1790185087 cites W2032485367 @default.
- W1790185087 cites W2034952062 @default.
- W1790185087 cites W2037680407 @default.
- W1790185087 cites W2040688689 @default.
- W1790185087 cites W2041993167 @default.
- W1790185087 cites W2047014086 @default.
- W1790185087 cites W2049557612 @default.
- W1790185087 cites W2051329373 @default.
- W1790185087 cites W2052222168 @default.
- W1790185087 cites W2055440829 @default.
- W1790185087 cites W2057919982 @default.
- W1790185087 cites W2059105920 @default.
- W1790185087 cites W2060682066 @default.
- W1790185087 cites W2064309380 @default.
- W1790185087 cites W2066961578 @default.
- W1790185087 cites W2068115489 @default.
- W1790185087 cites W2070139973 @default.
- W1790185087 cites W2077495163 @default.
- W1790185087 cites W2082181174 @default.
- W1790185087 cites W2083789858 @default.
- W1790185087 cites W2084310603 @default.
- W1790185087 cites W2086501247 @default.
- W1790185087 cites W2086549112 @default.
- W1790185087 cites W2086970589 @default.
- W1790185087 cites W2093308534 @default.
- W1790185087 cites W2095026426 @default.
- W1790185087 cites W2097542090 @default.
- W1790185087 cites W2098162750 @default.
- W1790185087 cites W2099436717 @default.
- W1790185087 cites W2100364658 @default.
- W1790185087 cites W2102699739 @default.
- W1790185087 cites W2103581424 @default.
- W1790185087 cites W2109449750 @default.
- W1790185087 cites W2109742508 @default.
- W1790185087 cites W2113142131 @default.
- W1790185087 cites W2116843182 @default.
- W1790185087 cites W2118921194 @default.
- W1790185087 cites W2122313592 @default.
- W1790185087 cites W2124956707 @default.
- W1790185087 cites W2125097638 @default.
- W1790185087 cites W2133453753 @default.
- W1790185087 cites W2137485270 @default.
- W1790185087 cites W2145387506 @default.
- W1790185087 cites W2148969624 @default.
- W1790185087 cites W2150678858 @default.
- W1790185087 cites W2154696002 @default.
- W1790185087 cites W2158225793 @default.
- W1790185087 cites W2161490648 @default.
- W1790185087 cites W2161707322 @default.
- W1790185087 cites W2162993561 @default.
- W1790185087 cites W2169893368 @default.
- W1790185087 cites W2170880987 @default.
- W1790185087 cites W2319361543 @default.
- W1790185087 cites W2334337188 @default.
- W1790185087 cites W4231603102 @default.
- W1790185087 cites W4238663920 @default.
- W1790185087 cites W4246679105 @default.
- W1790185087 cites W4376542631 @default.