FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1790207613> ?p ?o ?g. }

• W1790207613 endingPage "1463" @default.
• W1790207613 startingPage "1447" @default.
• W1790207613 abstract "The contribution of myeloid cells to tumour microenvironments is a decisive factor in cancer progression. Tumour-associated macrophages (TAMs) mediate tumour invasion and angiogenesis through matrix remodelling, immune modulation and release of pro-angiogenic cytokines. Nothing is known about how pathogenic bacteria affect myeloid cells in these processes. Here we show that Bartonella henselae, a bacterial pathogen causing vasculoproliferative diseases (bacillary angiomatosis), reprogrammes human myeloid angiogenic cells (MACs), a pro-angiogenic subset of circulating progenitor cells, towards a TAM-like phenotype with increased pro-angiogenic capacity. B. henselae infection resulted in inhibition of cell death, activation of angiogenic cellular programmes and induction of M2 macrophage polarization. MACs infected with B. henselae incorporated into endothelial sprouts and increased angiogenic growth. Infected MACs developed a vascular mimicry phenotype in vitro, and expression of B. henselae adhesin A was essential in inducing these angiogenic effects. Secretome analysis revealed that increased pro-angiogenic activities were associated with the creation of a tumour-like microenvironment dominated by angiogenic inflammatory cytokines and matrix remodelling compounds. Our results demonstrate that manipulation of myeloid cells by pathogenic bacteria can contribute to microenvironmental regulation of pathological tissue growth and suggest parallels underlying both bacterial infections and cancer." @default.
• W1790207613 created "2016-06-24" @default.
• W1790207613 creator A5015776991 @default.
• W1790207613 creator A5016924764 @default.
• W1790207613 creator A5018156469 @default.
• W1790207613 creator A5021511716 @default.
• W1790207613 creator A5021874719 @default.
• W1790207613 creator A5050230085 @default.
• W1790207613 creator A5056513847 @default.
• W1790207613 creator A5056998132 @default.
• W1790207613 creator A5058468216 @default.
• W1790207613 creator A5069627319 @default.
• W1790207613 creator A5082251197 @default.
• W1790207613 creator A5086893088 @default.
• W1790207613 date "2015-05-19" @default.
• W1790207613 modified "2023-09-26" @default.
• W1790207613 title "Reprogramming of myeloid angiogenic cells by<i>B</i><i>artonella henselae</i>leads to microenvironmental regulation of pathological angiogenesis" @default.
• W1790207613 cites W1491652527 @default.
• W1790207613 cites W1555312557 @default.
• W1790207613 cites W1599900825 @default.
• W1790207613 cites W166637581 @default.
• W1790207613 cites W1962869168 @default.
• W1790207613 cites W1970128919 @default.
• W1790207613 cites W1972794546 @default.
• W1790207613 cites W1973220859 @default.
• W1790207613 cites W1974554594 @default.
• W1790207613 cites W1975515187 @default.
• W1790207613 cites W1979491566 @default.
• W1790207613 cites W1982861164 @default.
• W1790207613 cites W1983141048 @default.
• W1790207613 cites W1986342542 @default.
• W1790207613 cites W1994363682 @default.
• W1790207613 cites W1998630067 @default.
• W1790207613 cites W1999579644 @default.
• W1790207613 cites W2008304553 @default.
• W1790207613 cites W2015346720 @default.
• W1790207613 cites W2016853666 @default.
• W1790207613 cites W2020822273 @default.
• W1790207613 cites W2021261789 @default.
• W1790207613 cites W2023164440 @default.
• W1790207613 cites W2027777116 @default.
• W1790207613 cites W2028681881 @default.
• W1790207613 cites W2033278321 @default.
• W1790207613 cites W2042831722 @default.
• W1790207613 cites W2055037877 @default.
• W1790207613 cites W2058648826 @default.
• W1790207613 cites W2058894435 @default.
• W1790207613 cites W2068524531 @default.
• W1790207613 cites W2078738962 @default.
• W1790207613 cites W2082876993 @default.
• W1790207613 cites W2085350659 @default.
• W1790207613 cites W2095818256 @default.
• W1790207613 cites W2102557353 @default.
• W1790207613 cites W2104327581 @default.
• W1790207613 cites W2109814631 @default.
• W1790207613 cites W2121165964 @default.
• W1790207613 cites W2122301597 @default.
• W1790207613 cites W2122598723 @default.
• W1790207613 cites W2123830992 @default.
• W1790207613 cites W2129321174 @default.
• W1790207613 cites W2135097960 @default.
• W1790207613 cites W2135398184 @default.
• W1790207613 cites W2138272556 @default.
• W1790207613 cites W2139015215 @default.
• W1790207613 cites W2141218575 @default.
• W1790207613 cites W2142394051 @default.
• W1790207613 cites W2147207558 @default.
• W1790207613 cites W2149142217 @default.
• W1790207613 cites W2158217645 @default.
• W1790207613 cites W2158758944 @default.
• W1790207613 cites W2159803625 @default.
• W1790207613 cites W2160697532 @default.
• W1790207613 cites W2163087495 @default.
• W1790207613 cites W4236554944 @default.
• W1790207613 doi "https://doi.org/10.1111/cmi.12447" @default.
• W1790207613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25857345" @default.
• W1790207613 hasPublicationYear "2015" @default.
• W1790207613 type Work @default.
• W1790207613 sameAs 1790207613 @default.
• W1790207613 citedByCount "14" @default.
• W1790207613 countsByYear W17902076132016 @default.
• W1790207613 countsByYear W17902076132017 @default.
• W1790207613 countsByYear W17902076132018 @default.
• W1790207613 countsByYear W17902076132019 @default.
• W1790207613 countsByYear W17902076132020 @default.
• W1790207613 countsByYear W17902076132021 @default.
• W1790207613 countsByYear W17902076132022 @default.
• W1790207613 countsByYear W17902076132023 @default.
• W1790207613 crossrefType "journal-article" @default.
• W1790207613 hasAuthorship W1790207613A5015776991 @default.
• W1790207613 hasAuthorship W1790207613A5016924764 @default.
• W1790207613 hasAuthorship W1790207613A5018156469 @default.
• W1790207613 hasAuthorship W1790207613A5021511716 @default.
• W1790207613 hasAuthorship W1790207613A5021874719 @default.
• W1790207613 hasAuthorship W1790207613A5050230085 @default.
• W1790207613 hasAuthorship W1790207613A5056513847 @default.
• W1790207613 hasAuthorship W1790207613A5056998132 @default.
• W1790207613 hasAuthorship W1790207613A5058468216 @default.

• next