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- W1790297216 abstract "In an era of development of disease-modifying treatments for neurodegenerative diseases, biomarkers have a crucial role in the identification of patients with appropriate histopathological targets. Multimodal neuroimaging—the integration of multiple imaging modalities into a single connectome—can make an essential contribution to this process. In a comprehensive Personal View, Stefan Teipel and his coauthors 1 Teipel S Drzezga A Grothe MJ et al. Multimodal imaging in Alzheimer's disease: validity and usefulness for early detection. Lancet Neurol. 2015; (published online Aug 27.)http://dx.doi.org/10.1016/S1474-4422(15)00093-9 PubMed Google Scholar outline the varieties of available neuroimaging for patients with Alzheimer's disease, and consider the clinical usefulness associated with each of these techniques. The authors provide an authoritative assessment of functional and structural imaging, including PET radioligands sensitive to amyloid, and PET glucose metabolic studies, and structural MRI studies of grey matter atrophy, diffusion tensor imaging, and resting state functional MRI techniques. The authors argue that these modalities can be used individually and serially to assist in the differential diagnosis of Alzheimer's disease. Multimodal imaging in Alzheimer's disease: validity and usefulness for early detectionAlzheimer's disease is a progressive neurodegenerative disease that typically manifests clinically as an isolated amnestic deficit that progresses to a characteristic dementia syndrome. Advances in neuroimaging research have enabled mapping of diverse molecular, functional, and structural aspects of Alzheimer's disease pathology in ever increasing temporal and regional detail. Accumulating evidence suggests that distinct types of imaging abnormalities related to Alzheimer's disease follow a consistent trajectory during pathogenesis of the disease, and that the first changes can be detected years before the disease manifests clinically. Full-Text PDF" @default.
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- W1790297216 date "2015-10-01" @default.
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- W1790297216 title "Integrated multimodal imaging in neurodegenerative disease" @default.
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- W1790297216 doi "https://doi.org/10.1016/s1474-4422(15)00182-9" @default.
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