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- W1790309710 abstract "Background: Type V collagen (COLV) has been recognized as an auto antigen involved in lung transplantation rejection and may be involved in systemic sclerosis pathogenesis (SSc), since immunization of healthy rabbits with this collagen induced an experimental model with similar characteristic of SSc patients. Objective: To investigate if SSc patient9s sera recognize COLV present in pulmonary tissue from this model and collagen isolated from supernatant culture of pulmonary fibroblasts from these patients. Methods: Immunofluorescence using collagen type I, III and IV adsorved sera from 8 SSc treatment naive patients and from 8 controls was performed to evaluate COLV reactivity in lung tissue from experimental model. These sera were also tested by immunoblotting to evaluate COLV reactivity in collagen isolated from SSc patient9s lung fibroblasts supernatants. Results: Positive immunofluorescence reaction was observed when the sera of SSc patients recognized epitopes of COLV in the experimetal model vessels walls and pulmonary interstitium contrasting with the negative reaction observed in the control. Morphometric analysis confirmed these findings, demonstrating a higher COLV reactivity to sera from SSc patients when compared to the control (p=0.0028). Immunoblotting showed that SSc patients sera strongly reacted to COLV standard and to the high molecular weight fragments of COLV isolated from SSc lung fibroblasts culture supernatants, different from control sera reactivity (p=0,02). Conclusions: SSc patient9s sera recognize COLV epitopes in experimental model lung tissue and SSc patient9s lung fibroblasts culture suggesting that this protein is an antigen involved in SSc pathogenesis." @default.
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- W1790309710 date "2011-09-01" @default.
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- W1790309710 title "Systemic sclerosis patients9 sera recognize collagen V in experimental scleroderma lung fibrosis" @default.
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